Androgen receptors and their uniqueness

Androgens and their receptors play an important role in female reproductive function. The potential role of androgens in the female body is determined by the presence of a significant pool of androgen receptors in the tissues of the reproductive system, including the endometrium, ovaries, fallopian tubes, and myometrium. The most impressive advances in the study of androgen receptors have recently been achieved due to an increasing growing attention to androgens, their role in human physiology in both men and women, the expediency of combined hormone therapy with androgens for various conditions accompanied by their deficiency, including for infertility and reproductive failures, in patients with a poor response and a low ovarian reserve and in the postmenopausal period. Conclusion. Thanks to modern biotechnology, the mechanisms underlying the activation of androgen receptors are becoming known, and their potential properties given in this paper are revealed. Discovering the details of the mechanism of action of androgen receptors and their effectors will help search for new methods of diagnosis, prediction, and introduction of personalized treatment regimens.

androgen receptors, androgens, testosterone, dihydrotestosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, infertility