Experience with a modified molded sorbent in the treatment of postpartum endometritis

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: To investigate the potential detoxifying effect of an application form of a polyvinylpyrrolidone-modified sorbent in the treatment of postpartum endometritis (PE).

Materials and methods: This retrospective study included 124 post-cesarean section patients with PE. The study group (n=63) received combined treatment including antibiotic therapy in combination with intrauterine administration of an applicative form of a polyvinylpyrrolidone-modified sorbent (VNIITU-1(PVP)). The control group (n=61) received standard antibacterial treatment.

Results: In patients with PE, predominantly cocci were isolated from the uterine cavity, including Enterococcus faecalis (26.6%) and Staphylococcus spp. (21.0%), and Enterococcus faecium (14.5%). Antibiotic resistance of the pathogens reached 53.6–68.3%. Atomic force microscopy and electron microscopy of sorbent rods extracted from the uterine cavity confirmed the high sorption capacity of VNIITU-1(PVP) against microorganisms, regardless of their antibiotic resistance. IR spectroscopy showed the high sorption capacity of the molded sorbent VNIITU-1 (PVP) against proteins and microbial toxins. Following treatment, uterine microflora growth was significantly reduced in the treated group, and the concentrations of IL-1β and TNF-α in the uterine aspirate decreased. The risk of hysterectomy in the study group was 14.5 times lower than in the control group (relative risk 0.069 (95% CI 0.009–0.51)).

Conclusion: Intrauterine use of VNITU-1 (PVP) molded sorbent in the complex therapy of PE improves treatment results and reduces the risk of hysterectomy by 14.5 times.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Sergey Barinov

Omsk State Medical University, Ministry of Health of Russia

Email: barinov_omsk@mail.ru
ORCID iD: 0000-0002-0357-7097

Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

Oksana Lazareva

Omsk State Medical University, Ministry of Health of Russia

Email: lazow@mail.ru
ORCID iD: 0000-0002-0895-4066

PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

Yuliya Tirskaya

Omsk State Medical University, Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: yulia.tirskaya@yandex.ru
ORCID iD: 0000-0001-5365-7119

Dr. Med. Sci., Associate Professor, Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

Tat’yana Kadtsyna

Omsk State Medical University, Ministry of Health of Russia

Email: tatianavlad@list.ru
ORCID iD: 0000-0002-0348-5985

PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

Yuriy Chulovsky

Omsk State Medical University, Ministry of Health of Russia

Email: akusheromsk@rambler.ru

PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

Anastasiya Orlitskaya

Omsk State Medical University, Ministry of Health of Russia

Email: orlitskayaad@mail.ru
ORCID iD: 0000-0002-1641-0720

Assistant, Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

Natal’ya Leont’eva

Federal Research Center Boreskov Institute of Catalysis

Email: science@ihcp.ru
ORCID iD: 0000-0001-5887-5860

PhD (Chemistry), Deputy Director for Science

Ресей, Omsk

Ekaterina Blauman

Omsk State Medical University, Ministry of Health of Russia

Email: blauman-es@yandex.ru
ORCID iD: 0000-0002-1498-0578

graduate student, Department of Obstetrics and Gynecology No. 2

Ресей, Omsk

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