Experience with a modified molded sorbent in the treatment of postpartum endometritis
- Authors: Barinov S.V.1, Lazareva O.V.1, Tirskaya Y.I.1, Kadtsyna T.V.1, Chulovsky Y.I.1, Orlitskaya A.D.1, Leont’eva N.N.2, Blauman E.S.1
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Affiliations:
- Omsk State Medical University, Ministry of Health of Russia
- Federal Research Center Boreskov Institute of Catalysis
- Issue: No 6 (2023)
- Pages: 89-98
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/562885
- DOI: https://doi.org/10.18565/aig.2023.37
- ID: 562885
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Abstract
Objective: To investigate the potential detoxifying effect of an application form of a polyvinylpyrrolidone-modified sorbent in the treatment of postpartum endometritis (PE).
Materials and methods: This retrospective study included 124 post-cesarean section patients with PE. The study group (n=63) received combined treatment including antibiotic therapy in combination with intrauterine administration of an applicative form of a polyvinylpyrrolidone-modified sorbent (VNIITU-1(PVP)). The control group (n=61) received standard antibacterial treatment.
Results: In patients with PE, predominantly cocci were isolated from the uterine cavity, including Enterococcus faecalis (26.6%) and Staphylococcus spp. (21.0%), and Enterococcus faecium (14.5%). Antibiotic resistance of the pathogens reached 53.6–68.3%. Atomic force microscopy and electron microscopy of sorbent rods extracted from the uterine cavity confirmed the high sorption capacity of VNIITU-1(PVP) against microorganisms, regardless of their antibiotic resistance. IR spectroscopy showed the high sorption capacity of the molded sorbent VNIITU-1 (PVP) against proteins and microbial toxins. Following treatment, uterine microflora growth was significantly reduced in the treated group, and the concentrations of IL-1β and TNF-α in the uterine aspirate decreased. The risk of hysterectomy in the study group was 14.5 times lower than in the control group (relative risk 0.069 (95% CI 0.009–0.51)).
Conclusion: Intrauterine use of VNITU-1 (PVP) molded sorbent in the complex therapy of PE improves treatment results and reduces the risk of hysterectomy by 14.5 times.
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About the authors
Sergey V. Barinov
Omsk State Medical University, Ministry of Health of Russia
Email: barinov_omsk@mail.ru
ORCID iD: 0000-0002-0357-7097
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskOksana V. Lazareva
Omsk State Medical University, Ministry of Health of Russia
Email: lazow@mail.ru
ORCID iD: 0000-0002-0895-4066
PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskYuliya I. Tirskaya
Omsk State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: yulia.tirskaya@yandex.ru
ORCID iD: 0000-0001-5365-7119
Dr. Med. Sci., Associate Professor, Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskTat’yana V. Kadtsyna
Omsk State Medical University, Ministry of Health of Russia
Email: tatianavlad@list.ru
ORCID iD: 0000-0002-0348-5985
PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskYuriy I. Chulovsky
Omsk State Medical University, Ministry of Health of Russia
Email: akusheromsk@rambler.ru
PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskAnastasiya D. Orlitskaya
Omsk State Medical University, Ministry of Health of Russia
Email: orlitskayaad@mail.ru
ORCID iD: 0000-0002-1641-0720
Assistant, Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskNatal’ya N. Leont’eva
Federal Research Center Boreskov Institute of Catalysis
Email: science@ihcp.ru
ORCID iD: 0000-0001-5887-5860
PhD (Chemistry), Deputy Director for Science
Russian Federation, OmskEkaterina S. Blauman
Omsk State Medical University, Ministry of Health of Russia
Email: blauman-es@yandex.ru
ORCID iD: 0000-0002-1498-0578
graduate student, Department of Obstetrics and Gynecology No. 2
Russian Federation, OmskReferences
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