Experience with a modified molded sorbent in the treatment of postpartum endometritis

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Objective: To investigate the potential detoxifying effect of an application form of a polyvinylpyrrolidone-modified sorbent in the treatment of postpartum endometritis (PE).

Materials and methods: This retrospective study included 124 post-cesarean section patients with PE. The study group (n=63) received combined treatment including antibiotic therapy in combination with intrauterine administration of an applicative form of a polyvinylpyrrolidone-modified sorbent (VNIITU-1(PVP)). The control group (n=61) received standard antibacterial treatment.

Results: In patients with PE, predominantly cocci were isolated from the uterine cavity, including Enterococcus faecalis (26.6%) and Staphylococcus spp. (21.0%), and Enterococcus faecium (14.5%). Antibiotic resistance of the pathogens reached 53.6–68.3%. Atomic force microscopy and electron microscopy of sorbent rods extracted from the uterine cavity confirmed the high sorption capacity of VNIITU-1(PVP) against microorganisms, regardless of their antibiotic resistance. IR spectroscopy showed the high sorption capacity of the molded sorbent VNIITU-1 (PVP) against proteins and microbial toxins. Following treatment, uterine microflora growth was significantly reduced in the treated group, and the concentrations of IL-1β and TNF-α in the uterine aspirate decreased. The risk of hysterectomy in the study group was 14.5 times lower than in the control group (relative risk 0.069 (95% CI 0.009–0.51)).

Conclusion: Intrauterine use of VNITU-1 (PVP) molded sorbent in the complex therapy of PE improves treatment results and reduces the risk of hysterectomy by 14.5 times.

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作者简介

Sergey Barinov

Omsk State Medical University, Ministry of Health of Russia

Email: barinov_omsk@mail.ru
ORCID iD: 0000-0002-0357-7097

Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

Oksana Lazareva

Omsk State Medical University, Ministry of Health of Russia

Email: lazow@mail.ru
ORCID iD: 0000-0002-0895-4066

PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

Yuliya Tirskaya

Omsk State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: yulia.tirskaya@yandex.ru
ORCID iD: 0000-0001-5365-7119

Dr. Med. Sci., Associate Professor, Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

Tat’yana Kadtsyna

Omsk State Medical University, Ministry of Health of Russia

Email: tatianavlad@list.ru
ORCID iD: 0000-0002-0348-5985

PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

Yuriy Chulovsky

Omsk State Medical University, Ministry of Health of Russia

Email: akusheromsk@rambler.ru

PhD, Associate Professor, Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

Anastasiya Orlitskaya

Omsk State Medical University, Ministry of Health of Russia

Email: orlitskayaad@mail.ru
ORCID iD: 0000-0002-1641-0720

Assistant, Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

Natal’ya Leont’eva

Federal Research Center Boreskov Institute of Catalysis

Email: science@ihcp.ru
ORCID iD: 0000-0001-5887-5860

PhD (Chemistry), Deputy Director for Science

俄罗斯联邦, Omsk

Ekaterina Blauman

Omsk State Medical University, Ministry of Health of Russia

Email: blauman-es@yandex.ru
ORCID iD: 0000-0002-1498-0578

graduate student, Department of Obstetrics and Gynecology No. 2

俄罗斯联邦, Omsk

参考

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