BRCA-associated breast cancer during pregnancy

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background: Breast cancer (BC) is the most common breast form diagnosed during pregnancy (from 1:3,000 to 1:10,000 cases) and is about 3% of all forms of BC. Physiological changes during pregnancy can hide the early signs of BC and, thereby, delay the diagnosis. When planning treatment during pregnancy, in each case, it is inevitable to discuss the gestation period, stage and form of BC.

Case report: The paper describes a clinical case of a 28-year-old pregnant woman with malignant breast neoplasm diagnosed at 9.1 weeks’ gestation, with a family history, BRCA1 gene mutation, and HER2neи amplification. Due to the patient's refusal to terminate the pregnancy, resection of the left breast with a nodular mass and biopsy of the sentinel lymph node biopsy were performed. A postoperative histological examination confirmed high-grade invasive ductal carcinoma; no metastases were found in the distant lymph nodes. A consultation of doctors recommended adjuvant chemotherapy according to the AS regimen with an inter-cycle drug administration period of 21 days and subsequent targeted therapy with trastuzumab after delivery.

Conclusion: The discussed case reflects the complexities of diagnosis and combination treatment in pregnant patients with BC.

Негізгі сөздер

Толық мәтін

Рұқсат жабық

Авторлар туралы

Lilia Bakhova

“Medical City” Multidisciplinary Clinical Medical Center; Tyumen State Medical University, Ministry of Health of Russia

Email: lilya8913@mail.ru
ORCID iD: 0000-0002-8918-6264
SPIN-код: 8832-3547

Senior Lecturer, Department of Oncology, Radiology and Radiotherapy, Institute of Clinical Medicine

Ресей, Tyumen; Tyumen

Tatiana Shevlyukova

Tyumen State Medical University, Ministry of Health of Russia

Email: tata21.01@mail.ru
ORCID iD: 0000-0002-7019-6630
SPIN-код: 5035-7233

Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, Institute of Maternity and Childhood

Ресей, Tyumen

Artem Keln

“Medical City” Multidisciplinary Clinical Medical Center; Tyumen State Medical University, Ministry of Health of Russia

Email: Artyom-keln@yandex.ru
ORCID iD: 0000-0002-5071-0604
SPIN-код: 9633-0276

PhD, Associate Professor, Department of Oncology, Radiology and Radiotherapy, Institute of Clinical Medicine

Ресей, Tyumen; Tyumen

Maxim Shvedsky

Tyumen State Medical University, Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: Shvedsky99@gmail.com
ORCID iD: 0000-0002-8854-2773
SPIN-код: 2797-1965

6th-year student, Institute of Clinical Medicine

Ресей, Tyumen

Elena Mateykovich

Tyumen State Medical University, Ministry of Health of Russia

Email: mat-maxim@yandex.ru
ORCID iD: 0000-0002-2612-7339
SPIN-код: 5864-8031

PhD, Associate Professor, Department of Obstetrics and Gynecology, Director of the Institute of Maternity and Childhood

Ресей, Tyumen

Oksana Nekrasova

“Medical City” Multidisciplinary Clinical Medical Center

Email: kuban.ksu@mail.ru

Head of OPLT Department No. 2

Ресей, Tyumen

Vlada Shkuratova

“Medical City” Multidisciplinary Clinical Medical Center

Email: shkuratovavv@mail.ru

doctor, OPLT No. 2

Ресей, Tyumen

Olga Karmaeva

“Medical City” Multidisciplinary Clinical Medical Center

Email: oskormina@mail.ru

Head of the Department of Molecular Genetics and Oncochemistry, Pathology Bureau

Ресей, Tyumen

Әдебиет тізімі

  1. Parazzini F., Franchi M., Tavani A., Negri E., Peccatori F.A. Frequency of pregnancy related cancer: A population-based linkage study in Lombardy, Italy. Int. J. Gynecol. Cancer. 2017; 27(3): 613-9. https://dx.doi.org/10.1097/IGC.0000000000000904.
  2. Bae S.Y., Jung S.P., Jung E.S., Park S.M., Lee S.K., Yu J.H. et al. Clinical characteristics and prognosis of pregnancy- associated breast cancer: poor survival of luminal B subtype. Oncology. 2018; 95(3): 163-9. https://dx.doi.org/10.1159/000488944.
  3. Рассказова Е.А., Зикиряходжаев А.Д., Каприн А.Д. Лечение рака молочной железы на фоне беременности. Акушерство и гинекология. 2021; 10: 174-8. [Rasskazova E.A., Zikiryakhodzhaev A.D., Kaprin A.D. Treatment for breast cancer during pregnancy. Obstetrics and Gynecology. 2021; (10): 174-8. (in Russian)]. https://dx.doi.org/10.18565/aig.2021.10.174-178.
  4. Пароконная А.А., Петровский А.В., Автомонов Д.Е., Сергеев Ю.С. Ошибки в диагностике рака молочной железы на фоне беременности и лактации на примере клинических случаев. Онкогинекология. 2021; 3: 17-23. [Parokonnaya A.A., Petrovsky A.V., Avtomonov D.E., Sergeev Yu.S. Errors in the diagnosis of breast cancer against the background of pregnancy and lactation on the example of clinical cases. Oncogynecology. 2021; (3): 17-23. (in Russian)].
  5. Шевлюкова Т.П., Бахова Л.А., Шведский М.С., Симонов А.В., Перымская А.С., Черная В.А. Изменение HER2-статуса на позитивный после неоадъювантной химиотерапии у пациентки с раком молочной железы. Женское здоровье и репродукция. 2023; 1: 64-8. [Shevlyukova T.P., Bahova L.A., Shvedsky M.S., Simonov A.V., Perymskaya A.S., Chernaya V.A. Change of HER2 status to positive after neoadjuvant chemotherapy in a patient with breast cancer. Women's Health and Reproduction. 2023; (1): 64-8. (in Russian)].
  6. Снежко О.А. Рак молочной железы и беременность. Главный врач Юга России. 2018; 4: 49-51. [Snezhko O.A. Breast cancer and pregnancy. Chief Physician of the South of Russia. 2018; (4): 49-51. (in Russian)].
  7. Шевлюкова Т.П., Бахова Л.А., Шведский М.С., Некрасова О.В., Шкуратова В.В., Федчук О.А. Эффективность неоадъювантной терапии в лечении больных местнораспространенным раком молочных желез. Доктор.Ру. 2023; 22(1): 28-32. [Shevlyukova T.P., Bahova L.A., Shvedsky M.S., Nekrasova O.V., Shkuratova V.V., Fedchuk O.A. The effectiveness of neoadjuvant therapy in the treatment of patients with locally advanced breast cancer. Doctor.Ru. 2023; 22(1): 28-32. (in Russian)]. https://dx.doi.org/10.31550/1727-2378-2023-22-1-28-32.
  8. Тилляшайхов М.Н., Шомансурова Н.С. Рак молочной железы и беременность. Клиническая и экспериментальная онкология. 2020; 1: 42-5. [Tillyashaykhov M.N., Shomansurova N.S. Breast cancer and pregnancy. Clinical and Experimental Oncology. 2020; (1): 42-5. (in Russian)].
  9. Доброхотова Ю.Э., Боровкова Е.И., Арутюнян А.М. Ассоциированный с беременностью рак молочной железы. Российский вестник акушера-гинеколога. 2019; 19(4): 77-81. [Dobrokhotova Iu.É., Borovkova E.I., Arutyunyan A.M. Pregnancy-associated breast cancer. Russian Bulletin of Obstetrician-Gynecologist. 2019; 19(4): 77 81. (in Russian)]. https://dx/doi.org/10.17116/rosakush20191904177.
  10. Доброхотова Ю.Э., Аракелов С.Э., Данелян С.Ж., Боровкова Е.И., Зыков А.Е., Залесская С.А., Нагайцева Е.А. Рак молочной железы, ассоциированный с беременностью: клинический случай. Гинекология. 2018; 20(1): 102-8. [Dobrokhotova Yu.E., Arakelov S.E., Danelyan S.Zh., Borovkova E.I., Zykov A.E., Zalesskaya S.A., Nagaytseva E.A. Breast cancer associated with pregnancy: a clinical case. Gynecology. 2018; 20(1): 102-8. (in Russian)]. https://dx.doi.org/10.26442/2079-5696_20.1.102-108.
  11. Петров Ю.А., Купина А.Д., Шаталов А.Е. Вероятность беременности и родов после рака молочной железы (обзор). Кубанский научный медицинский вестник. 2020; 27(5): 163-74. [Petrov Yu.A., Kupina A.D., Shatalov A.E. Pregnancy and labour likelihood after breast cancer (a review). Kuban Scientific Medical Bulletin. 2020; 27(5): 163-74. (in Russian)]. https://dx.doi.org/10.25207/1608-6228-2020-27-5-163-174.
  12. Обоскалова Т.А., Коваль М.В., Севостьянова О.Ю. Опыт персонифицированной тактики ведения пациенток с раком молочной железы, ассоциированным с беременностью. Пермский медицинский журнал. 2023; 40(2): 123-30. [Oboskalova T.A., Koval M.V., Sevostyanova O.Yu. Experience of personalized tactics of management of patients with breast cancer associated with pregnancy. Perm Medical Journal. 2023; 40(2): 123-30. (in Russian)].
  13. Андреева Н.Л. Рак молочной железы и беременность. Медицинские новости. 2019; 5: 4-8. [Andreyeva N.L. Breast cancer and pregnancy. Medical News. 2019; (5): 4-8. (in Russian)].
  14. Тер-Ованесов М.Д., Шаль Е.П., Кукош М.Ю., Оганисян А.Н. Рак молочной железы, ассоциированный с беременностью: диагностика, лечение, прогноз. Медицинский алфавит. 2018; 2(29): 10-6. [Ter-Ovanesov M.D., Shal E.P., Kukosh M.Yu., Oganesyan A.N. Breast cancer associated with pregnancy: diagnosis, treatment, prognosis. Medical Alphabet. 2018; 2(29): 10-6. (in Russian)].

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу
2. Figure. Polymerase chain reaction with Real Time PCR, qualitative analysis by melting curves

Жүктеу (93KB)
Метадеректер

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>