The effect of indolcarbinol on cyclic mastalgia in benign mammary dysplasia in routine clinical practice ("APHRODITE" study)

Мұқаба
  • Авторлар: Ashrafyan L.A.1, Rozhkova N.I.2,3, Prokopenko S.P.2,3, Meskikh E.V.4,5, Artymuk N.V.6, Belotserkovtseva L.D.7,8, Dolgushina V.F.9, Korotkikh N.V.10,11, Kuznetsova L.V.12, Kukarskaya I.I.13,14, Kononenko T.S.15, Marochko T.Y.6, Sokolov K.A.16, Verbitskaya Y.S.16
  • Мекемелер:
    1. Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
    2. P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological Center, Ministry of Health of Russia
    3. Peoples’ Friendship University of Russia
    4. Pirogov Russian National Research Medical University, Ministry of Health of Russia
    5. Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia
    6. Kemerovo State Medical University, Ministry of Health of Russia
    7. Surgut District Clinical Center for Maternal and Child Health
    8. Surgut State University
    9. South Ural State Medical University, Ministry of Health of Russia
    10. N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia
    11. Voronezh Regional Clinical Oncological Dispensary
    12. Almazov National Medical Research Center, Ministry of Health of Russia
    13. Tyumen State Medical University, Ministry of Health of Russia
    14. Tyumen Regional Perinatal Center
    15. Kuban State Medical University, Ministry of Health of Russia
    16. Alcea LLC
  • Шығарылым: № 2 (2024)
  • Беттер: 134-142
  • Бөлім: Exchange of Experience
  • URL: https://journals.eco-vector.com/0300-9092/article/view/631365
  • DOI: https://doi.org/10.18565/aig.2024.35
  • ID: 631365

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: The primary aim of the study was to evaluate the effect of Indinol Forto on pain syndrome in various benign breast diseases. The secondary aims included the assessment of the effect on the number and size of cysts in the mammary glands and evaluation of additional data on safety in routine clinical practice.

Materials and methods: These are the results of a prospective observational study “APHRODITE” of the drug Indinol Forto (indolcarbinol) which was conducted in 9 research centers of the Russian Federation with the participation of 100 women over the age of 18.

Results: Indolcarbinol therapy had a positive effect on reducing pain syndrome (mastodynia) after 3–6 months of treatment. The results of the ultrasound assessment and mammography showed a decrease in the total size of cysts, as well as a decrease in the proportion of women with dilated ducts of the mammary glands after 3 months of treatment. Longer use of indolcarbinol (6 months) was associated with a stronger effect. The patients tolerated indolcarbinol well and did not have undesirable or side effects.

Conclusion: The results of the study showed that indolcarbinol (Indinol Forto) caused a decrease in pain syndrome in patients with mastodynia in benign mammary dysplasia after 3–6 months of treatment. Indolcarbinol also resulted in a decrease in the total size of cysts and decrease in dilated ducts of the mammary glands in some women after 3 months of treatment. Thus, indolcarbinol appeared to be the only non-hormonal drug at the moment with a proven effect on the structure of breast tissue according to the results of the BI-RADS assessment.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Lev Ashrafyan

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: levaa2004@yahoo.com

Academician of the Russian Academy of Sciences, Professor, Dr.Med. Sci., Head of the Institute of Oncogynecology and Mammology

Ресей, 117997, Moscow, Ac. Oparina str., 4

Nadezhda Rozhkova

P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological Center, Ministry of Health of Russia; Peoples’ Friendship University of Russia

Email: nrozhkova2013@yandex.ru
ORCID iD: 0000-0003-0920-1549
SPIN-код: 8478-1840

Honored Scientist of the Russian Federation, Professor, Dr.Med. Sci., Head of the National Center for Oncology of the Reproductive Organs, Professor of the Department of Clinical Mammology, Radiation Diagnostics and Radiation Therapy of the FNMO MI

Ресей, 125284, Moscow, 2nd Botkinsky proezd, 3; 117198, Moscow, Miklukho-Maklaya str., 6

Sergey Prokopenko

P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological Center, Ministry of Health of Russia; Peoples’ Friendship University of Russia

Email: prokopenkosp@gmail.com
ORCID iD: 0000-0002-0369-5755
SPIN-код: 6987-9294
Scopus Author ID: 7004120546

MD, PhD, Associate Professor, Head of the Department of Complex Diagnostics and Interventional Radiology in Mammology, Head of the Department of Clinical Mammology, Radiation Diagnostics and Radiation Therapy of the FNMO MI

Ресей, 125284, Moscow, 2nd Botkinsky proezd, 3; 117198, Moscow, Miklukho-Maklaya str., 6

Elena Meskikh

Pirogov Russian National Research Medical University, Ministry of Health of Russia; Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia

Email: meskihelena@rambler.ru

Dr.Med. Sci., Professor of the Department of X-ray Radiology, doctor of the highest category, Chief Researcher at X-ray Radiological Laboratory

Ресей, 117997, Moscow, st. Profsoyuznaya, 86; 117997 Moscow, Profsoyuznaya str., 86

Natalia Artymuk

Kemerovo State Medical University, Ministry of Health of Russia

Email: artymuk@gmail.com
ORCID iD: 0000-0001-7014-6492

Dr.Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology named after Professor G.A. Ushakova

Ресей, 650060, Kemerovo, Voroshilova str., 22a

Larisa Belotserkovtseva

Surgut District Clinical Center for Maternal and Child Health; Surgut State University

Email: Lbelotserkovtseva@gmail.com

Dr.Med. Sci., Professor, Honored Doctor of the Russian Federation, President of the Surgut District Clinical Center for Maternal and Child Health, Head of Department of Obstetrics and Gynecology

Ресей, 628403, Khanty-Mansiysk Autonomous Okrug – Ugra, Surgut, Lenin Ave., 1; Surgut

Valentina Dolgushina

South Ural State Medical University, Ministry of Health of Russia

Email: dolgushinavf@yandex.ru

Professor, Dr.Med. Sci., Head of the Department of Obstetrics and Gynecology

Ресей, 454092, Chelyabinsk, Vorovskogo str., 64

Natalia Korotkikh

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia; Voronezh Regional Clinical Oncological Dispensary

Email: kornat78@mail.ru

MD, PhD, Associate Professor of Oncology Department, Head of the Department, Voronezh Regional Clinical Oncology Dispensary

Ресей, 394036, Voronezh, Studencheskaya str., 10; 394036, Voronezh, Vaitsekhovskogo str., 4

Lyubov Kuznetsova

Almazov National Medical Research Center, Ministry of Health of Russia

Email: Krivo73@mail.ru

MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology with the clinic of the institute of medical education, Head of the Research laboratory of Reproduction and Women’s Health

Ресей, 197341, St. Petersburg, Akkuratova str., 2

Irina Kukarskaya

Tyumen State Medical University, Ministry of Health of Russia; Tyumen Regional Perinatal Center

Email: kukarskaya@mail.ru

Dr.Med. Sci., Professor of the Department of Obstetrics, Gynecology and Reanimatology with a Course of Clinical Laboratory Diagnostics, Tyumen State Medical University, Chief Physician, Chief specialist in obstetrics and gynecology, Department of Health of the Tyumen Region, Honored doctor of the Russian Federation, Honorary healthcare worker of the Tyumen region

Ресей, 625023, Tyumen, Odesskaya str., 54; Tyumen

Tatyana Kononenko

Kuban State Medical University, Ministry of Health of Russia

Email: kononenkotc@yandex.ru

MD, PhD, Assistant of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Education and Training

Ресей, 350063, Krasnodar, Mitrofan Sedin str., 4 (Central microdistrict)

Tatiana Marochko

Kemerovo State Medical University, Ministry of Health of Russia

Email: marochko.2006.68@mail.ru
ORCID iD: 0000-0001-5641-5246

MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology named after Professor G.A. Ushakova

 

Ресей, 650060, Kemerovo, Voroshilova str., 22a

Kirill Sokolov

Alcea LLC

Email: kirill.sokolov@alceapharma.ru
ORCID iD: 0000-0002-8358-3963

MD, obstetrician-gynecologist, Medical Director

Ресей, 129110, Moscow, Olimpiysky Ave., 16, bld. 5

Yulia Verbitskaya

Alcea LLC

Email: Yulia.verbitskaya@alceapharma.ru
ORCID iD: 0009-0004-2960-8455

MD, PhD, Medical Advisor

Ресей, 129110, Moscow, Olimpiysky Ave., 16, bld. 5

Әдебиет тізімі

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