The effect of indolcarbinol on cyclic mastalgia in benign mammary dysplasia in routine clinical practice ("APHRODITE" study)
- Авторлар: Ashrafyan L.A.1, Rozhkova N.I.2,3, Prokopenko S.P.2,3, Meskikh E.V.4,5, Artymuk N.V.6, Belotserkovtseva L.D.7,8, Dolgushina V.F.9, Korotkikh N.V.10,11, Kuznetsova L.V.12, Kukarskaya I.I.13,14, Kononenko T.S.15, Marochko T.Y.6, Sokolov K.A.16, Verbitskaya Y.S.16
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Мекемелер:
- Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological Center, Ministry of Health of Russia
- Peoples’ Friendship University of Russia
- Pirogov Russian National Research Medical University, Ministry of Health of Russia
- Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia
- Kemerovo State Medical University, Ministry of Health of Russia
- Surgut District Clinical Center for Maternal and Child Health
- Surgut State University
- South Ural State Medical University, Ministry of Health of Russia
- N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia
- Voronezh Regional Clinical Oncological Dispensary
- Almazov National Medical Research Center, Ministry of Health of Russia
- Tyumen State Medical University, Ministry of Health of Russia
- Tyumen Regional Perinatal Center
- Kuban State Medical University, Ministry of Health of Russia
- Alcea LLC
- Шығарылым: № 2 (2024)
- Беттер: 134-142
- Бөлім: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/631365
- DOI: https://doi.org/10.18565/aig.2024.35
- ID: 631365
Дәйексөз келтіру
Аннотация
Objective: The primary aim of the study was to evaluate the effect of Indinol Forto on pain syndrome in various benign breast diseases. The secondary aims included the assessment of the effect on the number and size of cysts in the mammary glands and evaluation of additional data on safety in routine clinical practice.
Materials and methods: These are the results of a prospective observational study “APHRODITE” of the drug Indinol Forto (indolcarbinol) which was conducted in 9 research centers of the Russian Federation with the participation of 100 women over the age of 18.
Results: Indolcarbinol therapy had a positive effect on reducing pain syndrome (mastodynia) after 3–6 months of treatment. The results of the ultrasound assessment and mammography showed a decrease in the total size of cysts, as well as a decrease in the proportion of women with dilated ducts of the mammary glands after 3 months of treatment. Longer use of indolcarbinol (6 months) was associated with a stronger effect. The patients tolerated indolcarbinol well and did not have undesirable or side effects.
Conclusion: The results of the study showed that indolcarbinol (Indinol Forto) caused a decrease in pain syndrome in patients with mastodynia in benign mammary dysplasia after 3–6 months of treatment. Indolcarbinol also resulted in a decrease in the total size of cysts and decrease in dilated ducts of the mammary glands in some women after 3 months of treatment. Thus, indolcarbinol appeared to be the only non-hormonal drug at the moment with a proven effect on the structure of breast tissue according to the results of the BI-RADS assessment.
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Авторлар туралы
Lev Ashrafyan
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Хат алмасуға жауапты Автор.
Email: levaa2004@yahoo.com
Academician of the Russian Academy of Sciences, Professor, Dr.Med. Sci., Head of the Institute of Oncogynecology and Mammology
Ресей, 117997, Moscow, Ac. Oparina str., 4Nadezhda Rozhkova
P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological Center, Ministry of Health of Russia; Peoples’ Friendship University of Russia
Email: nrozhkova2013@yandex.ru
ORCID iD: 0000-0003-0920-1549
SPIN-код: 8478-1840
Honored Scientist of the Russian Federation, Professor, Dr.Med. Sci., Head of the National Center for Oncology of the Reproductive Organs, Professor of the Department of Clinical Mammology, Radiation Diagnostics and Radiation Therapy of the FNMO MI
Ресей, 125284, Moscow, 2nd Botkinsky proezd, 3; 117198, Moscow, Miklukho-Maklaya str., 6Sergey Prokopenko
P. Hertsen Moscow Oncology Research Institute, National Medical Research Radiological Center, Ministry of Health of Russia; Peoples’ Friendship University of Russia
Email: prokopenkosp@gmail.com
ORCID iD: 0000-0002-0369-5755
SPIN-код: 6987-9294
Scopus Author ID: 7004120546
MD, PhD, Associate Professor, Head of the Department of Complex Diagnostics and Interventional Radiology in Mammology, Head of the Department of Clinical Mammology, Radiation Diagnostics and Radiation Therapy of the FNMO MI
Ресей, 125284, Moscow, 2nd Botkinsky proezd, 3; 117198, Moscow, Miklukho-Maklaya str., 6Elena Meskikh
Pirogov Russian National Research Medical University, Ministry of Health of Russia; Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia
Email: meskihelena@rambler.ru
Dr.Med. Sci., Professor of the Department of X-ray Radiology, doctor of the highest category, Chief Researcher at X-ray Radiological Laboratory
Ресей, 117997, Moscow, st. Profsoyuznaya, 86; 117997 Moscow, Profsoyuznaya str., 86Natalia Artymuk
Kemerovo State Medical University, Ministry of Health of Russia
Email: artymuk@gmail.com
ORCID iD: 0000-0001-7014-6492
Dr.Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology named after Professor G.A. Ushakova
Ресей, 650060, Kemerovo, Voroshilova str., 22aLarisa Belotserkovtseva
Surgut District Clinical Center for Maternal and Child Health; Surgut State University
Email: Lbelotserkovtseva@gmail.com
Dr.Med. Sci., Professor, Honored Doctor of the Russian Federation, President of the Surgut District Clinical Center for Maternal and Child Health, Head of Department of Obstetrics and Gynecology
Ресей, 628403, Khanty-Mansiysk Autonomous Okrug – Ugra, Surgut, Lenin Ave., 1; SurgutValentina Dolgushina
South Ural State Medical University, Ministry of Health of Russia
Email: dolgushinavf@yandex.ru
Professor, Dr.Med. Sci., Head of the Department of Obstetrics and Gynecology
Ресей, 454092, Chelyabinsk, Vorovskogo str., 64Natalia Korotkikh
N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia; Voronezh Regional Clinical Oncological Dispensary
Email: kornat78@mail.ru
MD, PhD, Associate Professor of Oncology Department, Head of the Department, Voronezh Regional Clinical Oncology Dispensary
Ресей, 394036, Voronezh, Studencheskaya str., 10; 394036, Voronezh, Vaitsekhovskogo str., 4Lyubov Kuznetsova
Almazov National Medical Research Center, Ministry of Health of Russia
Email: Krivo73@mail.ru
MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology with the clinic of the institute of medical education, Head of the Research laboratory of Reproduction and Women’s Health
Ресей, 197341, St. Petersburg, Akkuratova str., 2Irina Kukarskaya
Tyumen State Medical University, Ministry of Health of Russia; Tyumen Regional Perinatal Center
Email: kukarskaya@mail.ru
Dr.Med. Sci., Professor of the Department of Obstetrics, Gynecology and Reanimatology with a Course of Clinical Laboratory Diagnostics, Tyumen State Medical University, Chief Physician, Chief specialist in obstetrics and gynecology, Department of Health of the Tyumen Region, Honored doctor of the Russian Federation, Honorary healthcare worker of the Tyumen region
Ресей, 625023, Tyumen, Odesskaya str., 54; TyumenTatyana Kononenko
Kuban State Medical University, Ministry of Health of Russia
Email: kononenkotc@yandex.ru
MD, PhD, Assistant of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Education and Training
Ресей, 350063, Krasnodar, Mitrofan Sedin str., 4 (Central microdistrict)Tatiana Marochko
Kemerovo State Medical University, Ministry of Health of Russia
Email: marochko.2006.68@mail.ru
ORCID iD: 0000-0001-5641-5246
MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology named after Professor G.A. Ushakova
Ресей, 650060, Kemerovo, Voroshilova str., 22a
Kirill Sokolov
Alcea LLC
Email: kirill.sokolov@alceapharma.ru
ORCID iD: 0000-0002-8358-3963
MD, obstetrician-gynecologist, Medical Director
Ресей, 129110, Moscow, Olimpiysky Ave., 16, bld. 5Yulia Verbitskaya
Alcea LLC
Email: Yulia.verbitskaya@alceapharma.ru
ORCID iD: 0009-0004-2960-8455
MD, PhD, Medical Advisor
Ресей, 129110, Moscow, Olimpiysky Ave., 16, bld. 5Әдебиет тізімі
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