Placental insufficiency and miscarriage in patients with chronic viral infections: Immunological aspects


Citar

Texto integral

Resumo

Objective: to assess a role of the cytotoxic link of the immune system and proinflammatory cytokines in the genesis of placental insufficiency and miscarriage in females with chronic viral infections. Setting: Department of Obstetrics and Gynecology, Medical Prophylactic Faculty, I. M. Sechenov Moscow Medical Academy. Design: a prospective cohort study. Subjects: 81 pregnant women with chronic viral infections and 100 patients in the first, second, and third trimesters of pregnancy (a control group). Methods: plasma cell immunity parameters (CD3, CD4, CD8, CD16, and CD25) were investigated by flow cytometry and the levels of extracellular proinflammatory (IL-2, IL-6, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10) were measured by enzyme immunoassay. Placental insufficiency was diagnosed by the data of ultrasound and Doppler studies, and the level of placental hormones. Results: activation of cytotoxic immunity (CD8 +, CD16 +, CD56 +), T-lymphocytic activation markers (CD25 +) and increased synthesis of proinflammatory cytokines (IL-2 and TNF-α) were revealed in pregnant women with viral infections as compared with the control group. These changes were observed throughout pregnancy starting from early gestational periods and they were accompanied by a reduction of Th2-pathway cytokines (IL-4 and IL-10). Conclusion: stratified analysis revealed the maximum increase in the count of CDS8 +, CD56, CD25, IL-2, TNF-α, and a reduction in IL-4 and IL-10 in patients with viral infections with the development of placental insufficiency and miscarriage.

Texto integral

Acesso é fechado

Sobre autores

N. Dolgushina

Bibliografia

  1. Верясов В. H., Кирющенков П. А., Соснина В. В. и др. // Мед. иммунол. - 2001. - Т. 3, № 2. - С. 250.
  2. Кидралиева А. С., Сидельникова В. М., Сухих Г. Т., Карлова Т. Ю. // Мед. иммунол. - 2001. - Т. 3, № 2. - С. 251.
  3. Козлова C. H., Колесникова Т. И., Агафонов С. Б. и др. // Мед. иммунол. - 2001. - Т. 3, № 2. - С. 251-252.
  4. Кудряшова А. В., Сотникова Н. Ю. // Мед. иммунол. - 2001. - Т. 3, № 2. - С. 253.
  5. Павлов О. В., Лалаян Д. В., Сельков С. А., Аржанова О. Н. // Бюл. экспер. биол. - 2003. - № 4. - С. 441-444.
  6. Сотникова Н. Ю., Ациферова Ю. С., Крошкина Н. В., Кудряшова А. В. // Мед. иммунол. - 2001. - Т. 3, № 2. - С. 259.
  7. Aoki K., Kajiura S., Matsumoto Y. et al. // Lancet. - 1995. - Vol. 345, N 8961. - P. 1340-1342.
  8. Arechavaleta-Velasco F., Kol H., Strauss J. F. 3rd, Parry S. // J. Reprod. Immunol. - 2002. - Vol. 55, N 1-2. - P. 113-121.
  9. Asrankulova û. B., Rizopulu A. P., Kurbanov D. D. // Zh Mikrobiol Epidemiol Immunobiol. - 2004. - Vol. 4. - P 84-86.
  10. Clark D. A., Arck P. C., Chaouat G. // Am. J. Immunol. - 1999. - Vol. 41. - P. 5-22.
  11. Ellermunn-Erikscn S. // Virol. J. - 2005. - Vol. 2, N 59.
  12. Girardі G., Yaritin D., Thurman J. M. et al. // J. Exp. Med. - 2006. - Vol. 203. - P. 2165-2175.
  13. Hill J. A., Polgar K., Anderson D. J. // J. A. M. A. - 1995. - Vol. 273, N 24. - P. 1933-1936.
  14. Hunt J. S., Robertson S. A. // J. Reprod. Immunol. - 1996. - Vol. 32, N 1. - P. 1-25.
  15. Jordan J. A., Huff D., DeLoia J. A. // Clin. Diagn. Lab. Immunol. - 2001. - Vol. 8, N 2. - P. 288-292.
  16. Raghupathy R., Makhseed M. et al. // Hum. Reprod. - 2000. - Vol. 15. - P. 713-718.
  17. Raghupathy R. // Semin. Immunol. - 2001. - Vol. 13, N 4. - P. 210-227.
  18. Uchide N., Suzuki A., Ohyama K. et al. // Placenta. - 2006. - Vol. 27, N 6-7. - P. 678-690.
  19. Weaver C. C., Burgess S. C., Nalson P. D. et al. // Placenta. - 2005. - Vol. 26, N 2-3. - P. 138-147.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Declaração de direitos autorais © Bionika Media, 2008