Value of angiogenic growth factors in complicated pregnancy in women with chronic venous insufficiency
- Autores: Sokolyan A.V.1, Murashko AV1, Krechetova LV1, Ziganshina MM1, Shetikova OV1, Sukhikh GT1, Sokolyan AV2, Murashko AV2, Krechetova LV2, Ziganshina MM2, Shetikova OV2, Sukhikh GT2
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Afiliações:
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
- Edição: Nº 3 (2009)
- Páginas: 42-45
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246116
- ID: 246116
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Resumo
Blood was taken from the ulnar vein of the patients during the first, second, and third trimesters of pregnancy. Serum angiogenic markers were measured in pg/ml by ELISA; PlGF was assayed using test systems/kits (R&D Systems Quintikine, Minneapolis, USA). VEGFR-1 was determined by the kits manufactured by Bender Medsystems (USA).
In the patients with CVI in PI and in those with FGR, and preeclampsia, the mean level of VEGFR-1 was established to be significantly increased throughout pregnancy as compared with that in healthy women. The concentration of PlGF was higher in patients with PI or FGR while the level of this growth factor in women with preeclampsia was significantly lower than that in healthy pregnant women from the first trimester. With a VEGFR-1 level of above 3700 pg/ml, there was an increased risk for FGR (RR 1.97; 95% CI 1.98-4.94; p = 0.043); with a PlGF concentration of below 178 pg/ml, there was a high risk for preeclampsia (RR 2.57; 95% CI 1.21-5.46; p = 0.024). This abnormal course of pregnancy was ascertained to be accompanied by a statistically significant increase in VEGFR-1/PlGF ratio. Abnormal pregnancy was marked by impaired balance between pro- and antiangiogenic growth factors, in this connection the determination of the levels of VEGFR-1 and PlGF, their ratio in particular, at first trimester is of great importance for the prediction of pregnancy complications, such as PI, FGR, and preeclampsia in pregnant women with CVI.
Sobre autores
Anzhela Sokolyan
A Murashko
L Krechetova
M Ziganshina
O Shetikova
G Sukhikh
A Sokolyan
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical TechnologiesV. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
A Murashko
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical TechnologiesV. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
L Krechetova
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical TechnologiesV. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
M Ziganshina
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical TechnologiesV. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
O Shetikova
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical TechnologiesV. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
G Sukhikh
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical TechnologiesV. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies
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