Early diagnosis of fetal chromosomal anomaly by the OSCAR program


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Abstract

The purpose of the study was to evaluate the efficiency of the One Stop Clinic for Assessment of Risk (OSCAR) program for the early detection of fetal chromosomal anormaly. The study group included 618 patients at 11-14 weeks gestational age. The comprehensive study comprised medicogenetic counseling, ultrasonography, and determination of the blood levels of biochemical markers. The individual risk for birth of a baby with trisomy 21, 18, or 13, monosomy X, and polyploidy was calculated using a computer Life Cycle program. Chorionic biopsy was made in patients at increased risk for chromosomal anomaly for fetal karyotyping. The prospective study suggests that the OSCAR program is highly effective. The sensitivity of combined prenatal screening for fetal chromosomal diseases in the first trimester, by taking into account the age of a pregnant woman, ultrasound markers of chromosomal anomaly, and the level of biochemical markers, was 97.6% with 7.5% frequency of false-positive results.

About the authors

V A Gnetestskaya

Center of Family Planning and Reproduction, Department of Health Care, Moscow

Email: prenatal@list.ru
Center of Family Planning and Reproduction, Department of Health Care, Moscow

M A Kurtser

Center of Family Planning and Reproduction, Department of Health Care, Moscow

Center of Family Planning and Reproduction, Department of Health Care, Moscow

O L Malmberg

Perinatal Medical Center, Moscow

Perinatal Medical Center, Moscow

M E Belkovskaya

Perinatal Medical Center, Moscow

Perinatal Medical Center, Moscow

N G Panina

Perinatal Medical Center, Moscow

Perinatal Medical Center, Moscow

Ye V Dubrovina

Center of Family Planning and Reproduction, Department of Health Care, Moscow

Center of Family Planning and Reproduction, Department of Health Care, Moscow

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