GENETIC RISK FACTORS FOR OBSTETRIC COMPLICATIONS OF SPONTANEOUS OR ASSISTED REPRODUCTIVE TECHNOLOGY PREGNANCY


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Resumo

Objective. To study the role of gene polymorphism associated with the formation of the mother-placenta-fetus system in the development of obstetric complications after assisted reproductive technologies (ART). Subjects and methods. A group study included 167 pregnant women (whose mean age was 34.4±4.3 years) after ART. A control group comprised 145 women with spontaneous singleton pregnancy (mean age 29.9±4.7 years). Polymorphisms of the cytokine genes participating in implantation and placentation (IL-10, IL-6, IL-6R), regulating the formation of the placental vascular network (VEGFA), the genes controlling placental metabolic function (PPARG, IGF II), and the blood coagulation system genes (F2, F5, FGB, ITGA2, ITGB3, SERPINE1) and folate cycle enzymes (MTHFR, MTR, MTRR) were studied. Results. The polymorphisms of the genes (IL-10 -592 А/С, VEGFA -2578 A>C, SERPINE1 -675 5G>4G, IL6-174 C>G, VEGFA -634 G>C, PPARG C>G [Pro12Ala]) are associated with the development of obstetric complications irrespective of the procedure of pregnancy achievement, which reflects their involvement in different stages of pathogenesis.

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Sobre autores

N. ALEKSANDROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: N_aleksandrova@oparina4.ru
Moscow

A. DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

O. BAYEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

G. SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

Bibliografia

  1. Стрижаков А.Н. и др. Роль ангиогенных факторов роста в прогнозировании плацентарной недостаточности // Вопр. гин., акуш. и перинатол. — 2009. — Т. 8, № 4. — С. 5-11.
  2. Anteby Y., Greenfield C., Natanson-Yaron S. Vascular endothelial growth factor, epidermal growth factor and fibroblast growth factor-4 and -10 stimulate trophoblast plasminogen activator system and metalloproteinase-9 // Mol. Hum. Reprod. - 2004. - Vol. 10. - P. 229-223.
  3. Banyasz I., Szabo S., Bokodi G. et al. Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsia // Mol. Hum. Reprod. - 2006. - Vol. 12. - P. 233-236.
  4. Carmeliet P., Ferreira V., Breier G. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGFA allele // Nature. - 1996. - Vol. 380. - P. 435-439.
  5. Constancia M., Hemberger M., Hughes J. et al. Placental-specific IGF2 is a major modulator of placental and fetal growth. // Nature. - 2002. - Vol. 417. - P. 945-948.
  6. Coulam C.B., Jeyendran R.S. Vascular endothelial growth factor gene polymorphisms and recurrent pregnancy loss // Am. J. Reprod. Immunol. - 2008. - Vol. 59. - P. 301-305.
  7. Ferrara N., Carver-Moore K., Chen H. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGFA gene // Nature. - 1996. - Vol. 380. - P. 439-442.
  8. Ghezzi F., Cohen J., Tolosa J.E. et al. Microbial invasion of the amniotic cavity is associated with increased concentrations of amniotic fluid interleukin-6 soluble receptor // Am. J. Obstet. Gynecol. - 1996. - Vol. 174. - P. 402.
  9. Giquel C., Rossignol S., Cabrol S. et al. Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndrome // Nat. Genet. - 2005. - Vol. 37. -P. 1003-1007.
  10. Hartel C., Finas D., Ahrens P. et al. Interleukin 6 -174 G/C promoter polymorphism and pregnancy complications: Results of a prospective cohort study in 1626 pregnant women // Am. J. Reprod. Immunol. - 2008. - Vol. 59, № 4. -P. 347-351.
  11. Kimatrai M., Blanco O., Munoz-Fernandez R. et al. Contractile activity of human decidual stromal cells. II. Effect of interleukin-10 // J. Clin. Endocrinol. Metab. - 2005. -Vol. 90. - P. 6126-6130.
  12. Meirhaeghe A., Boreham C.A.G., Murray L.J. et al. A possible role for the PPARG Pro12Ala polymorphism in preterm birth // Diabetes. - 2007. - Vol. 56. - P. 494-498.
  13. Miyaki K., Murata M., Kikuchi H. et al. Assessment of tailor-made prevention of atherosclerosis with folic acid supplementation: randomized, double-blind, placebocontrolled trials in each MTHFR C677T genotype // J. Hum. Genet. - 2005. - Vol. 50, № 5. - P. 241-248.
  14. Murtaugh M.A., Curtin K., Sweeney C. et al. Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer // Cancer Causes Control. - 2007. - Vol. 18, № 2. - P. 153-163.
  15. Nordengren J., Pilka R., Noskova V. et al. Differential localization and expression of urokinase plasminogen activator(uPA), its receptor(uPAR), and its inhibitor (PAI-1) mRNA and protein in endometrial tissue during the menstrual cycle // Mol. Hum. Reprod. - 2004. - Vol. 10. -P. 655-663.
  16. Papazoglou D., Galazios G., Papatheodorou K. et al. Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss // Fertil. and Steril. - 2005. -Vol. 83. - P. 959-963.
  17. Randhawa R., Cohen P. The role of the insulin-like growth factor system in prenatal growth // Mol. Genet. Metab. - 2005. - Vol. 86. - P. 84-90.
  18. Schneider B.P., Radovich M., Sledge G.W. et al. Association of polymorphisms of angiogenesis genes with breast cancer // Breast Cancer Res. Treat. - 2008. - Vol. 111. -P. 157-163.
  19. Shim J.Y., Jun J.K., Jung B.K. et al. Vascular endothelial growth factor gene +936 C/T polymorphism is associated with preeclampsia in Korean women // Am. J. Obstet. Gynecol. - 2007. - Vol. 197. - P. 271; 1-4.
  20. Sparago A., Cerrato F., Vernucci M. et al. Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome // Nat. Genet. - 2004. -Vol. 36. - P. 958-996.
  21. Velez D.R., Menon R., Thorsen P. et al. Ethnic differences in interleukin 6 (IL-6) and IL6 receptor genes in spontaneous preterm birth and effects on amniotic fluid protein levels // Ann. Hum. Genet. - 2007. - Vol. 71. - P. 586-600.

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