GENETIC RISK FACTORS FOR OBSTETRIC COMPLICATIONS OF SPONTANEOUS OR ASSISTED REPRODUCTIVE TECHNOLOGY PREGNANCY


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Abstract

Objective. To study the role of gene polymorphism associated with the formation of the mother-placenta-fetus system in the development of obstetric complications after assisted reproductive technologies (ART). Subjects and methods. A group study included 167 pregnant women (whose mean age was 34.4±4.3 years) after ART. A control group comprised 145 women with spontaneous singleton pregnancy (mean age 29.9±4.7 years). Polymorphisms of the cytokine genes participating in implantation and placentation (IL-10, IL-6, IL-6R), regulating the formation of the placental vascular network (VEGFA), the genes controlling placental metabolic function (PPARG, IGF II), and the blood coagulation system genes (F2, F5, FGB, ITGA2, ITGB3, SERPINE1) and folate cycle enzymes (MTHFR, MTR, MTRR) were studied. Results. The polymorphisms of the genes (IL-10 -592 А/С, VEGFA -2578 A>C, SERPINE1 -675 5G>4G, IL6-174 C>G, VEGFA -634 G>C, PPARG C>G [Pro12Ala]) are associated with the development of obstetric complications irrespective of the procedure of pregnancy achievement, which reflects their involvement in different stages of pathogenesis.

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About the authors

N. V ALEKSANDROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: N_aleksandrova@oparina4.ru
Moscow

A. E DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

O. R BAYEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

G. T SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

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