THE RATE OF NEONATAL INFECTIOUS AND INFLAMMATORY DISEASES IN PLACENTAL INSUFFICIENCY

Objective. To estimate the rate of neonatal infectious and inflammatory diseases in placental insufficiency (PI) of infectious genesis. Subjects and methods. 1500 case histories were retrospectively analyzed; of which 500 showed infectious and inflammatory diseases. Two hundred and eighty-two cases diagnosed as having PI during pregnancy were selected. Moreover, complex prevention and therapy of PI were performed in 187 women and 95 patients were untreated. The babies were divided into 3 groups: 1) 85 neonatal infants diagnosed as having pneumonia (P23; P24); 2) 107 babies diagnosed as having omphalitis (P38), conjunctivitis (P39.1), and rhinitis (P28.8); 3) 90 newborn infants diagnosed as having other infectious diseases specif ic to the perinatal period (P39). Results. Infectious and inflammatory diseases ran much more severely in babies born to mothers with decompensated PI. Pneumonia was predominant in the structure of the diseases. At the same time the detection of markers for systemic inflammatory reaction not always reflected the presence of infectious and inflammatory disease in the newborns. Furthermore, there was a direct relationship between the manifestation of infectious and inflammatory diseases in neonatal infants and the correction of PI in their mothers (all untreated women gave birth to babies with infectious diseases). Conclusion. The findings suggest that maternal infection plays a role not only in causing pregnancy complications, premature labor, fetal growth retardation, etc., but also in developing intrauterine infection and in showing the infection in neonatality.

placental insufficiency, intrauterine infection, fetal growth retardation