Use of β-alanine for therapy for estrogen deficiency in surgical menopause


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Resumo

Objective. To study the efficacy of β-alanine in the therapy of climacteric manifestations in women during surgical menopause. Subject and methods. The randomized parallel-group trial enrolled 59 patients aged over 45 years with surgical menopause. Results. The international menopausal index (IMI) decreased from 19.3±2.4 to 9.1±1.5 during 3-month therapy with β-alanine (p < 0.001). The latter affected only the magnitude of neuroautonomic and, to a lesser degree, psychoemotional symptoms. Therapeutic effectiveness increased with the longer use of the drug (pairwise comparisons during 3 treatment intervals; p = 0.003; p = 0.001; p = 0.006). As compared with the control group, IMI reduced by 26, 45, and 55% after 1, 2, and 3 months of therapy, respectively (p = 0.045; p = 0.004; p = 0.001). Conclusion. β-alanine treatment reduced the number and magnitude of neuroautonomic symptoms during surgical menopause. The effectiveness of the therapy increased with its longer duration.

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Sobre autores

Irina Evtushenko

Siberian State Medical University

Email: evtushenko_id@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology

Ilya Petrov

Siberian State Medical University

Email: obgyn@sibmail.com
Candidate of Medicine, Assistant of the Department of Obstetrics and Gynecology

Marina Petrova

Siberian State Medical University

Email: marina.gin20ll@mail.ru
Candidate of Medicine, Assistant Professor of the Department of Obstetrics and Gynecology

Vladimir Tkachev

Siberian State Medical University

Email: volnikt@mail.ru
Candidate of Medicine, Assistant Professor of the Department of Obstetrics and Gynecology

Svetlana Kislyak

Siberian State Medical University

Email: svetlana.kislyak@gmail.com
student of the Department of General Medicine

Bibliografia

  1. Калинченко С.Ю., Апетов С.С. Особенности коррекции гипогонадизма у женщинприхирургической менопаузе. Гинекология.2011;13(3): 19-23
  2. Вихляева Е.М., ред. Руководство по эндокринной гинекологии. М.: МИА; 2002. 765 с
  3. Кулаков В.И., Сметник В.П., ред. Руководство по климактерию. М.: МИА; 2001. 685 с
  4. Григорян О.Р., Андреева Е.Н., Дедов И.И. Менопаузальный синдром у женщин с нарушениями углеводного обмена. Научно-практическое руководство. 2-е изд. М.; 2011: 60-9
  5. Громова О.А., Торшин И.Ю., Лиманова О.А., Никонов А.А. Патофизиология вегетативно-сосудистых пароксизмов (приливы) у женщин в период менопаузы и механизм действия бета-аланина. Новая клинико-фармакологическая концепция. Гинекология. 2010; 12(2): 29-36
  6. Юренева С.В., Моисеев С.В. Негормональные методы лечения вазомоторных симптомов менопаузы с позиции медицины, основанной на доказательствах. Клиническая фармакология и терапия. 2010; 2: 69-74
  7. Delacroix P. Abufene 400 mg. Double blind placebo-controlled trial. Laboratoires Adrian-Marinier; 1978
  8. Roueche J. et al. Clinical trial report of a double-blind study of beta-alanine versus placebo in the treatment of hot flushes caused by climacteric syndrome and by the menopause. Laboratoires Doms-Adrian; 1991

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