Use of β-alanine for therapy for estrogen deficiency in surgical menopause


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Abstract

Objective. To study the efficacy of β-alanine in the therapy of climacteric manifestations in women during surgical menopause. Subject and methods. The randomized parallel-group trial enrolled 59 patients aged over 45 years with surgical menopause. Results. The international menopausal index (IMI) decreased from 19.3±2.4 to 9.1±1.5 during 3-month therapy with β-alanine (p < 0.001). The latter affected only the magnitude of neuroautonomic and, to a lesser degree, psychoemotional symptoms. Therapeutic effectiveness increased with the longer use of the drug (pairwise comparisons during 3 treatment intervals; p = 0.003; p = 0.001; p = 0.006). As compared with the control group, IMI reduced by 26, 45, and 55% after 1, 2, and 3 months of therapy, respectively (p = 0.045; p = 0.004; p = 0.001). Conclusion. β-alanine treatment reduced the number and magnitude of neuroautonomic symptoms during surgical menopause. The effectiveness of the therapy increased with its longer duration.

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About the authors

Irina Dmitrievna Evtushenko

Siberian State Medical University

Email: evtushenko_id@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology

Ilya Alekseevich Petrov

Siberian State Medical University

Email: obgyn@sibmail.com
Candidate of Medicine, Assistant of the Department of Obstetrics and Gynecology

Marina Sergeevna Petrova

Siberian State Medical University

Email: marina.gin20ll@mail.ru
Candidate of Medicine, Assistant Professor of the Department of Obstetrics and Gynecology

Vladimir Nikolaevich Tkachev

Siberian State Medical University

Email: volnikt@mail.ru
Candidate of Medicine, Assistant Professor of the Department of Obstetrics and Gynecology

Svetlana Viktorovna Kislyak

Siberian State Medical University

Email: svetlana.kislyak@gmail.com
student of the Department of General Medicine

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