AUTOANTIBODIES AGAINST ENDOTHELIAL ANTIGENS IN PREECLAMPSIA


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Resumo

Objective. To determine the spectrum of serum autoantibodies against endothelial cells and components of the glycocalyx in patients with preeclampsia and to investigate their relationship. Subjects and methods. A prospective case-control study was conducted. The activity of antibody binding to endothelial EA.hy926 cells and the level of peripheral blood anti-hyaluronic acid antibodies were determined in 28patients with preeclampsia and 30 apparently healthy pregnant women in the third trimester. Results. In preeclampsia, there was an enhanced binding of immunoglobulin G antibodies to endothelial cell antigens, as well as an increased level of immunoglobulin G antibodies against hyaluronic acid [-4GlcA[31- 3 GlcNA eft!- In and its repeating disaccharide unit GlcA/31-3GlcNA eft. A negative correlation was found between the binding of anti-endothelial cell antibodies and anti-hyaluronic antibodies. Conclusion. The findings may expand knowledge of the pathogenesis of preeclampsia and its practical realization into the diagnosis and prognosis of the disease.

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Sobre autores

Marina Ziganshina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mmz@mail.ru
research fellow of the Laboratory of clinical immunology Moscow 117997, Ac. Oparina str. 4

Nadegda Shilova

Russia Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: pumatnv@gmail.com
candidate of chemical sciences, leading research fellow of the Laboratory of Carbohydrate Chemistry Moscow 117437, Miklukho-Maklaya str. 16/10, Russia

Nailia Khasbiullina

Russia Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: crosbreed@list.ru
junior research fellow of the Laboratory of Carbohydrate Chemistry Moscow 117437, Miklukho-Maklaya str. 16/10, Russia

Maxim Novakouski

Russia Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: maxushob@gmail.com
candidate of chemical sciences, research fellow of the Laboratory of Carbohydrate Chemistry Moscow 117437, Miklukho-Maklaya str. 16/10, Russia

Marina Nikolaeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: MNikolaeva@oparina4.ru
M.D., leading research fellow of the Laboratory of clinical immunology Moscow 117997, Ac. Oparina str. 4

Natalia Kan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
MD, PhD, the Head of the Obstetrical Observational Department Moscow 117997, Ac. Oparina str. 4

Olga Vavina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_vavina@oparina4.ru
fellow Moscow 117997, Ac. Oparina str. 4

Anastasia Nikolaeva

City Clinical Hospital Sixty-Four, Moscow Healthcare Department

Email: irgly@rambler.ru
MD, the Head of the branch of City Clinical Hospital Sixty-Four Moscow 117292, Vavilova str. 61, Russia

Nataliya Tyutyunnik

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_tyutyunnik@oparina4.ru
the resident Moscow 117997, Ac. Oparina str. 4

Olga Sergunina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_sergunina@oparina4.ru
the doctor of the Obstetrical Observational Department Moscow 117997, Ac. Oparina str. 4

Llze Bot

Leiden University

Email: i.bot@lacdr.leidenuniv.nl
PhD, MD, senior scientist, Leiden Academic Center for Drug Research 2333 CC , Lieden, Einsteinweg 55, the Netherlands

Victor Tyutyunnik

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
PhD, MD, the Head of the obstetric physiological department Moscow 117997, Ac. Oparina str. 4

Nikolai Bovin

Russia Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: bovin@carb.ibch.ru
PhD, MD, professor, the Head of the Laboratory of Carbohydrate Chemistry Moscow 117437, Miklukho-Maklaya str. 16/10, Russia

Gennady Sukhikh

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru
PhD, MD, professor, academician of RAS, Director Moscow 117997, Ac. Oparina str. 4

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