Role of preimplantation genetic screening in enhancing the effectiveness of assisted reproductive technology programs in late reproductive-aged patients


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Objective. To investigate the effectiveness of assisted reproductive technology (ART)programs in late reproductive-aged (LRA) patients undergoing preimplantation genetic screening (PGS). Subjects and methods. The prospective cohort study enrolled 160 LRA patients (aged >35 years) with infertility of different genesis who were stratified according to PGS: Group 1 included 87 LRA patients who had not undergone PGS; Group 2 consisted of 73 LRA patients who had undergone PGS. The latter was performed by fluorescence in situ hybridization (FISH) or array-based comparative genomic hybridization (aCGH) on day 3 or day 5 of embryo culture, respectively. Results. In LRA patients who had undergone PGS, the chances of getting pregnant were 2.1 times higher and those of live birth were 2 times higher than in LRA patients who had not undergone PGS (OR for pregnancy = 2.1 (95% CI = 1.04; 4.2); OR for live birth = 2.0 (95% CI = 0.98; 4.1)). In vitro fertilization (IVF) with PCS was most effective (by 2.6 times) in a group of patients aged 36 to 39 years. The most effective method of PGS was aCGH on day 5 of embryo culture, which can enhance the efficiency of ART programs by 3.1 times in LRA patients. Conclusion. IVF/PGS in LRA patients aged 36 to 39 years is a technique that can increase the probability of pregnancy and live birth, by selecting euploid embryos.

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Sobre autores

Ekaterina Beik

National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia named after Academician V.I. Kulakov

Email: e_beik@oparina4.ru
M.D., post-graduate student, Department of ART in the treatment of infertility

Olga Korotchenko

National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia named after Academician V.I. Kulakov

Email: okorotchenko@mail.ru
M.D., Post-graduate student, Department of ART in the treatment of infertility

Anna Gvozdeva

M.V. Lomonosov Moscow State University

Email: gvozdevaannalech@gmail.com
Undergraduate of the Faculty of Fundamental Medicine

Anastasia Syrkasheva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia named after Academician V.I. Kulakov

Email: a_syrkasheva@oparina4.ru
M.D., Ph.D., Researcher of the Department of ART in the treatment of infertility

Nataliya Dolgushina

National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia named after Academician V.I. Kulakov

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

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