Evaluation of the medicinal properties of a contraceptive containing ethinylestradiol and chlormadinone acetate

Nataliya Mikhaylovna Podzolkova; Подзолкова Наталия Михайловна; Yuliya Alekseevna Koloda; Колода Юлия Алексеевна; Vera Vyacheslavovna Korennaya; Коренная Вера Вячеславовна; Viktor Alekseevich Aksenenko; Аксененко Виктор Алексеевич; Nailya Edgarovna Bakirova; Бакирова Наиля Эдгаровна; Anna Valeryevna Vorontsova; Воронцова Анна Валерьевна; Elena Vladimirovna Enkova; Енькова Елена Владимировна; L. Yu Karakhalis; Карахалис Людмила Юрьевна; Nadezhda Yuryevna Katkova; Каткова Надежда Юрьевна; Galina Nikolaevna Minkina; Минкина Галина Николаевна; Elena V. Misharina; Мишарина Елена Владимировна; Anna Alexandrovna Olina; Олина Анна Александровна; L. S Sotnikova; Сотникова Лариса Степановна; Natalia V. Spiridonova; Спиридонова Наталья Владимировна; Ludmila Vladimirovna Tkachenko; Ткаченко Людмила Владимировна; Armine Robertovna Khachaturyan; Хачатурян Арминэ Робертовна

doi:10.18565/aig.2018.3.109-115

Evaluation of the medicinal properties of a contraceptive containing ethinylestradiol and chlormadinone acetate

Autores: Podzolkova N.M.¹, Koloda Y.A.¹, Korennaya V.V.¹, Aksenenko V.A.², Bakirova N.E.³^,4, Vorontsova A.V.⁵, Enkova E.V.⁶, Karakhalis L.Y.⁷, Katkova N.Y.⁸, Minkina G.N.⁹, Misharina E.V.¹⁰, Olina A.A.¹¹, Sotnikova L.S¹², Spiridonova N.V.¹³, Tkachenko L.V.¹⁴, Khachaturyan A.R.¹⁵
Afiliações:
1. Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
2. Stavropol State Medical University
3. Kazan (Volga) Federal University
4. KORL LLC
5. Ural State Medical University, Ministry of Health of Russia
6. N.N. Burdenko Voronezh State Medical University
7. Kuban State Medical University
8. Nizhny Novgorod State Medical Academy
9. A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
10. D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
11. Academician E.A. Vagner Perm State Medical University
12. Siberian State Medical University, Ministry of Health of Russia
13. Samara State Medical University
14. Volgograd State Medical University
15. Saint Petersburg State University
Edição: Nº 3 (2018)
Páginas: 109-115
Seção: Articles
URL: https://journals.eco-vector.com/0300-9092/article/view/248212
DOI: https://doi.org/10.18565/aig.2018.3.109-115
ID: 248212

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Objective. To evaluate the medicinal properties of an agent containing ethinylestradiol (EE) and chlormadinone acetate (CMA) in contraceptive-needing patients within the framework of the pharmacological epidemiological observational project. Subjects and methods. The investigation enrolled 161 contraception-needing patients. All the patients had no contraindications to combined oral contraceptives (COCs) and conditions in which COCs should be used with caution. All the women took EE in combination with CMA in a 21/7 cyclic regimen for contraception. To evaluate the medicinal properties of the agent, the investigators studied its effects on the nature of menstruation and related symptoms (tenderness, frequency of breast pain prior to menstruation, abundant discharge), and the skin (acne frequency and severity, skin oiliness). Results. During the investigation, there were pronounced changes associated with a decrease in complaints related to painful menstruation, their abundance, premenstrual breast pain; acne severity and higher skin fat content reduced. Conclusion. The findings may consider COC with EE/CMA as an agent having an anti-androgenic effect that can reduce the frequency and degree of manifestation of acne, have a positive effect on the nature of menstruation.

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ethinylestradiol, chlormadinone acetate, medicinal properties, painful menstruation

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Здравоохранение в России. 2015. Статистический сборник. М.: Росстат; 2015. 174с.
Токова З.З., Прилепская В.Н., Гата А.С., Куземин А.А. Статистика современных методов контрацепции в федеральных округах России. Гинекология. 2016; 18(4): 68-73.
De Irala J., Osorio A., Carlos S., Lopez-del Burgo C. Choice of birth control methods among European women and the role of partners and providers. Contraception. 2011; 84(6): 558-64.
Mueck A.O., Seeger H., Rabe T. Hormonal contraception and risk of endometrial cancer: a systematic review. Endocr. Relat. Cancer. 2010; 17(4): R263-71.
Siskind V., Green A., Bain C., Purdie D. Beyond ovulation: oral contraceptives and epithelial cancer. Epidemiology. 2000; 11(2): 106-10.
Basetti C., Bravi F., Negri E., La Vecchia C. Oral contraceptives and colorectal cancer risk: a systematic review and meta-analysis. Hum. Reprod. Update. 2009; 150(5): 489-98.
Legro R.S., Arslanian S.A., Ehrmann D.A., Hoeger K.M., Murad M.H., Pasquali R. et al. Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 2013; 98(12): 4565-92.
Гребень Н.Ф. Психологические тесты для профессионалов. Минск: Современная школа; 2007. 496с.

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Evaluation of the medicinal properties of a contraceptive containing ethinylestradiol and chlormadinone acetate

Texto integral

Resumo

Palavras-chave

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Sobre autores

Nataliya Podzolkova

Yuliya Koloda

Vera Korennaya

Viktor Aksenenko

Nailya Bakirova

Anna Vorontsova

Elena Enkova

L. Karakhalis

Nadezhda Katkova

Galina Minkina

Elena Misharina

Anna Olina

L. Sotnikova

Natalia Spiridonova

Ludmila Tkachenko

Armine Khachaturyan

Bibliografia

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