Immune antiviral drug therapy in patients with HPV-associated cervical intraepithelial neoplasia grade I

Objective. To improve quality of life in patients with cervical intraepithelial neoplasia grade I (CIN I) associated with human papillomavirus ((HPV) infection due to a medical treatment without destructive intervention. Subjects and methods. The investigation of relevance to specialties was conducted at the Department of Obstetrics and Gynecology, Penza Institute for Postgraduate Training for Physicians. Examinations were made in 86 reproductive-aged women with cervical pathology and high-risk HPV (hr-HPV) who had attended outpatient clinics in Saransk. Results. The investigation established the patterns of hr-HPVprevalence in women with CIN I, as well as its relationship to the functioning of the immune system. Dysregulation that was manifested in the predominance of anti-inflammatory cytokines over pro-inflammatory ones increased the probability of virus persistence in the body, which is likely to contribute to the development of neoplastic processes and more advanced intraepithelial lesions. Conclusion. The data obtained from the conducted studies allow optimization of the management of patients with HPV-induced CINI without destructive therapies.

cervical intraepithelial neoplasia, human papillomavirus, cervical cancer, polymerase chain reaction, genotyping, high risk for cancer, viral load, gamma-interferon, allokin-alpha, interleukin-18, tumor necrosis factor-alpha, Alloferon