Analysis of the prevalence and viral load of different human papillomavirus types in the regions of the Russian Federation


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Abstract

Objective. To analyze the pattern of HPV carriage and the characteristics of viral load of HPV type 21 in different regions of the Russian Federation. Subjects and methods. A total of32,650patients were surveyed. DNA samples collected by scraping the epithelium of the cervical canal (in women) or the urethra (in men) were analyzed using real-time PCR detection. Results. At least one type of HPV was detected in 38.9% of the patients; two or more types were simultaneously identified in 32.8%. The largest proportion of patients with two or more types of HPV was observed in women aged less than 25 and 55-60years and in men aged 50-55-years. The most common HPV type 16 was detected in 27.3% of HPV-positive men and 25.6% of women. HPV type 44 was found to be most common in the Far Eastern District and the North Caucasus Federal District; HPV types 52, 53, 58 were in the Volga Federal District. Higher viral load was more frequently detected in young women. Conclusion. There were regional differences in the prevalence of HPV types. The carriage of more than one type of HPV was shown to be related to age and sex. Viral load differences according to the type of HPV were described.

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About the authors

Andrey Y. Donnikov

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
PhD, head of the laboratory of the molecular-genetics methods

Mikahil I. Markelov

N.I. Pirogov Russian National Research Medical University

Email: m.markelovl994@mail.ru
student, Medical-Biological Department, division of the medical biochemistry.

Tatyana Yu. Pestrikova

Far Eastern State Medical University

Email: typ50@rambler.ru
MD, professor, head of the Department of Obstetrics and Gynecology

Elena A. Yurasova

Far Eastern State Medical University

Email: urasovaea@yandex.ru
MD, professor, Department of Obstetrics and Gynecology

Anastacia V. Kotelnikova

Far Eastern State Medical University

Email: tempo-m@mail.ru
assistant of the Department of Obstetrics and Gynecology

Ekaterina S. Voroshilina

Ural State Medical University

Email: voroshilina@gmail.com
MD, assistant professor

Evgeny E. Plotko

Medical Center «Harmony»

Email: plotko@g-mc.ru
MD, chief doctor

Tatiana S. Belokhvostikova

Irkutsk State Medical Academy

Email: Belohvostikova20ll@yandex.ru
MD, head of the Department of Clinical Laboratory Diagnostics

Valentina P. Bondareva

Stavropol Regional Clinical Consultative and Diagnostic Center

Email: nakldc@skkdc.ru
MD, head of Laboratory Diagnistics Department

Maria A. Chernikova

DC «Laboratory diagnostics - Asclepius»

Email: skibam@bk.ru
head of the Department of Clinical Laboratory Diagnostics

Svetlana N. Vashchenko

DC «Laboratory diagnostics - Asclepius»

Email: svetlanaasklepiy@mail.ru
MD, gynecologist-endocrinologist

Viktoria V. Chernikova

DC «Laboratory diagnostics - Asclepius»

Email: viktoriachern@mail.ru
biologist

Liubov I. Stankevich

Gontard & Cie Group

Email: Lubov.stan@gmail.com
MD

Maria Yu. Khasina

LLC «Unilab»; Far Eastern Federal University

Email: 2985823@mail.ru
PhD, medical development director; associate professor, School of Biomedicine

Irina S. Galkina

Central Research Institute of Health Organization and Informatization; Company DNA-Technology Co

Email: Galkina@dna-technology.ru
PhD in chemistry, Senior Researcher; Chief Marketing Officer

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