Preeclampsia and HELLP syndrome as a manifestation of thrombotic microangiopathy


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详细

Thrombotic microangiopathy is one of the severest thrombotic events, which is characterized by affected microvessels in different organs and accompanied by thrombocytopenia and hemolytic anemia. The term thrombotic microangiopathy encompasses several nosological entities characterized by different mechanisms of microthrombosis. At present, thrombotic microangiopathy includes thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, heparin-induced thrombocytopenia, and HELLP syndrome. Pregnancy is one of the most important triggers of thrombotic microangiopathy. This fact opens up broad prospects for studying the pathogenesis of thrombotic microangiopathy in the context of physiological changes in hemostasis during pregnancy. At the same time, the discovery of molecular mechanisms of thrombotic microangiopathy allows afresh look at the pathogenesis of pregnancy-associated thrombotic events and at that of the so-called placental obstetric complications, including the severe forms of preeclampsia.

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作者简介

Alexander Makatsaria

I.M. Sechenov First Moscow State Medical

Email: gemostasis@mail.ru
Department of Obstetrics and Gynecology, Faculty of Preventive Medicine

Svetlana Akinshina

I.M. Sechenov First Moscow State Medical

Email: gemostasis@mail.ru
Department of Obstetrics and Gynecology, Faculty of Preventive Medicine

Viktoria Bitsadze

I.M. Sechenov First Moscow State Medical

Email: gemostasis@mail.ru
Department of Obstetrics and Gynecology, Faculty of Preventive Medicine

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