The levels of interleukin-6, soluble interleukin-6 and vascular endothelial growth factor receptors during delivery at term, threatened preterm labor, and in preeclampsia


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Objective. To study of the serum levels of Interleukin-6 (IL-6), soluble IL-6 and vascular endothelial growth factor (VEGF) receptors in women during delivery at term, threatened preterm labor, and in preeclampsia. Subjects and methods. A total of 85 pregnant women who were divided into 4 groups were examined. Group 1 included 35 women with physiological delivery; Group 2 consisted of 11 with threatened preterm labor; Group 3 comprised 23 with preeclampsia; Group 4 (a control group) included 16 with physiological pregnancy. A solidphase enzyme-linked immunoabsorbent assay was used to determine the serum levels of IL-6, soluble IL-6 and VEGF receptors. Results. The level of IL-6 was shown to increase dramatically in women with physiological delivery while the level in those with threatened preterm labor was approximately the same as that in the controls. The content of soluble IL-6 receptor was opposite to that of IL-6. The level of soluble VEGF receptor 1 reduced in threatened preterm labor and increases in physiological delivery and preeclampsia.

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作者简介

Vladimir Shcherbakov

Research Institute of Experimental and Clinical Medicine

Email: Shcherbakov_VI@mail.ru
doctor of medical sciences, research fellow of the Immunology Laboratory

Ivan Pozdnyakov

Novosibirsk State Medical University; Novosibirsk City Clinical Perinatal Center

Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology; Chief Physician

Anna Shirinskaya

Novosibirsk City Clinical Perinatal Center

Email: anncharm2004@mail.ru
obstetrician-gynecologist women’s consultation No. 2.

Mikhail Volkov

Clinical Maternity Hospital Six

Email: michaelis67@mail.ru
obstetrician-gynecologist, women’s consultation

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