The role of gene polymorphisms of the hemostatic system and folate cycle enzymes in the development of retrochorial hematoma


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To assess the role of gene polymorphisms of the hemostatic system and folate cycle enzymes in the development of retrochorial hematoma (RCH). Subjects and methods. The investigation enrolled 305pregnant women who were examined and treated at the Rostov Regional Perinatal Center. All the pregnant women were divided into 2 groups: 1) 238pregnant women with RCH; 2) (a control group) 67 pregnant women with clinically normal pregnancy without RCH, as evidenced by first-trimester ultrasound. To identify genetic markers determining the development of chorion detachment, the pregnant women in the first-trimester underwent genotyping of four polymorphic loci of the folate cycle genes (MTHFR C677T, MTHFR A1298C, MTR А2756G, and MTRR А66С) and eight hemostatic genes (F2 G20210A, F5 G1691A, G10976A F7, F13 G103T, FGB G-455А, C807TITGA2, ITGB3 Т1565С, and SERPINE1-675 5G/4G). Results. Significant differences were obtained in a study of the distribution of the alleles G10976A of the F7 gene, G103T of the F13 gene, and G-455A of the FGB gene in a group of pregnant women with RCH versus that of pregnant women with clinically normal pregnancy. The A allele of F7 G10976A, the T allele F13 G103T, and the A allele of FGB G-455A were found to be associated with a high risk for RCH. Conclusion. The F7 gene (proconvertin, CF VII) polymorphism G10976A (rs 6046), the F13 gene (Fibrinase, CF XIII) G103T polymorphism (rs 5985), and the FGB gene (fibrinogen β-chain) polymorphism G-455A (rs 1800790) are associated with the risk of RCH.

全文:

受限制的访问

作者简介

Natalia Kuznetsova

Rostov State Medical University

Email: lauranb@inbox.ru
Ph.D. in medical sciences, the assistant of the Department of Obstetrics, Gynecology and Reproduction № 4

Irina Bushtyreva

Rostov State Medical University; Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kio4@mail.ru
MD, Professor, the Head of the Department of Obstetrics, Gynecology and Reproduction № 4; leading researcher

Andrey Donnikov

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
Ph.D. in medical sciences, leading researcher of Laboratory of molecular genetic methods

Elena Mashkina

Federal Autonomous Educational Institution of Higher Education the Southern Federal University

Email: lenmash@mail.ru
Ph.D. in biological sciences, the assistant of the genetics department

Violetta Dybova

Perinatal Center

Email: viola-kovaleva@mail.ru
obstetrician-gynecologist Rostov-on-Don

参考

  1. Pri-Paz S.M., D’Alton M.E. Placental abruption. In: Copel J.A., ed. Obstetric imaging. Saunders; 2012: 470-3.
  2. Asato K., Mekaru K., Heshiki C., Sugiyama H., Kinjyo T., Masamoto H., Aoki Y. Subchorionic hematoma occurs more frequently in in vitro fertilization pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2014; 181: 41-4.
  3. Tuuli M.G., Norman S.M., Odibo A.O., Macones G.A., Cahill A.G. Perinatal outcomes in women with subchorionic hematoma: a systematic review and metaanalysis. Obstet. Gynecol. 2011; 117(5): 1205-12.
  4. Poursadegh Zonouzi A., Chaparzadeh N., Ghorbian S., Sadaghiani M.M., Farzadi L., Ghasemzadeh A. et al. The association between thrombophilic gene mutations and recurrent pregnancy loss. J. Assist. Reprod. Genet. 2013; 30(10): 1353-9.
  5. Davenport W.B., Kutteh W.H. Inherited thrombophilias and adverse pregnancy outcomes: a review of screening patterns and recommendations. Obstet. Gynecol. Clin. North Am. 2014; 41(1): 133-44.
  6. Буштырева И.О., Кузнецова Н.Б., Пелогеина Е.И. Роль генетических полиморфизмов, ассоциированных с нарушением фолатного цикла и риском развития тромбофилии, в генезе ретрохориальной гематомы в I триместре беременности. Современные технологии в медицине. 2015; 7(3): 84-9. [Bushtyreva I.O., Kuznetsova N.B., Pelogeina E.I. Genetic Polymorphisms Associated with Impaired Folate Cycle and the Risk of Thrombophilia in Patients with Retrochorial Hematoma in the First Trimester of Pregnancy. Sovremennye tehnologii v medicine. 2015; 7(3): 84-89. (in Russian)]
  7. Seremak-Mrozikiewicz A., Drews K., Kurzawinska G., Barlik M., Mrozikiewicz P.M. The connection between Arg353Gln polymorphism of coagulation factor VII and recurrent miscarriages. Ginekol. Pol. 2009; 80(1): 8-13.
  8. Elmahgoub I.R., Afify R.A., Abdel Aal A.A., El-Sherbiny W.S. Prevalence of coagulation factor XIII and plasminogen activator inhibitor-1 gene polymorphisms among Egyptian women suffering from unexplained primary recurrent miscarriage. J. Reprod. Immunol. 2014; 103: 18-22.
  9. Dossenbach-Glaninger A., van Trotsenburg M., Dossenbach M., Oberkanins C., Moritz A., Krugluger W. et al. Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss. Clin. Chem. 2003; 49(7): 1081-6.
  10. Bagheri M., Rad I.A., Omrani M.D., Nanbaksh F. The Val34Leu genetic variation in the A subunit of coagulation factor XIII in recurrent spontaneous abortion. Syst. Biol. Reprod. Med. 2011; 57(5): 261-4.
  11. Wells P.S., Anderson J.L., Scarvelis D.K., Doucette S.P., Gagnon F. Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis. Am. J. Epidemiol. 2006; 164(2): 101-9.
  12. Dossenbach-Glaninger A., van Trotsenburg M., Oberkanins C., Atamaniuk J. Risk for early pregnancy loss by factor XIII Val34Leu: the impact of fibrinogen concentration. J. Clin. Lab. Anal. 2013; 27(6): 444-9.
  13. Bagoly Z., Koncz Z., Hársfalvi J., Muszbek L. Factor XIII, clot structure, thrombosis. Thromb. Res. 2012; 129(3): 382-7.
  14. Humphries S.E., Cook M., Dubowitz M., Stirling Y., Meade T.W. Role of genetic variation at the fibrinogen locus in determination of plasma fibrinogen concentrations. Lancet. 1987; 1(8548): 1452-5.
  15. Torabi R., Zarei S., Zeraati H., Zarnani A.H., Akhondi M.M., Hadavi R. et al. Combination of thrombophilic gene polymorphisms as a cause of increased the risk of recurrent pregnancy loss. J. Reprod. Infertil. 2012; 13(2): 89-94.
  16. Alexandrova N.V., Baev O.R., Suchihch G.T., Shchegolev A.I., Trofimov D.Y., Donnikov A.E. Thrombophilia polymorphisms in women with pregnancy conceived by assisted reproductive technology. Reprod. Biomed. Online. 2010; 20(Suppl. 3): S1.
  17. Кирющенков П.А., Ходжаева З.С., Тетруашвили Н.К., Донников А.Е., Белоусов Д.М., Андамова Е.В., Тамбовцева М.А. Значение полиморфизма гена ингибитора активатора плазминогена I типа (SERPINE1: 5G>4G) при отслойках хориона и плаценты на ранних сроках беременности. Акушерство и гинекология. 2012; 5: 34-7. [Kiryushchenkov P.A., Khodzhayeva Z.S., Tetruashvili N.K., Donnikov A.E., Belousov D.M., Andamova E.V., Tambovtseva M.A. Significance of plasminogen activator inhibitor type 1 gene (SERPINE1: 5G>4G) polymorphism in chorionic detachment and placental abruption in early pregnancy. Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2012; (5): 34-7. (in Russian)]
  18. Said J.M., Higgins J.R., Moses E.K., Walker S.P., Borg A.J., Monagle P.T. et al. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet. Gynecol. 2010; 115(1): 5-13.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2017
##common.cookie##