SCREENING FOR SERUM THYROID-STIMULATING HORMONE LEVELS IN INFERTILE WOMEN AS THE BASIS FOR PREDICTING THE OUTCOMES OF ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS


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Objective. To estimate the blood levels of thyroid-stimulating hormone (TSH) in infertile women and to evaluate its effect on the outcome of infertility treatment using assisted reproductive technologies (ART). Subjects and methods. The study sample included 171 married couples with a conf irmed diagnosis of Infertility, who referred for IVF and IVF/ICSI in the period 2016 to 2017. All the female patients underwent superovulation induction in the IVF and IVF/ICSI program. Serum TSH levels were measured one month before the start of an ART session. Results. Medical records indicated that autoimmune thyroiditis was diagnosed in 56 (32.7%) of the examinees. Patients with a TSH concentration of less than 1.4 mIU/ml were statistically significantly more frequently observed to have a positive infertility treatment outcome manifested by the highest proportion of ART deliveries (75.8%) than in those with that of more than 1.4 mIU/ml (p <0.001). Conclusion. The given results show that the decrease in blood TSH levels to less than 1.4 mIU/ml before ART is associated with the higher incidence of clinical pregnancy resulting from ART.

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作者简介

Svetlana Paskar

Acad. I.P. Pavlov First Saint Petersburg State Medical Unive

Email: paskarsvetlana@mail.ru
PhD student of the Department of Obstetrics and Gynecology and Neonatology 197022 Russia, Saint Petersburg, L’va Tolstogo st., 6/8

Alla Kalugina

Acad. I.P. Pavlov First Saint Petersburg State Medical Unive

MD, Professor of the Department of Obstetrics and Gynecology and Neonatology 197022 Russia, Saint Petersburg, L’va Tolstogo st., 6/8

参考

  1. Stagnaro-Green A., Abalovich M., Alexander E., Azizi F., Mestman J., Negro R. et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011; 21(10): 1081-125. https://doi.org/10.1089/thy.2011.0087
  2. Rijal B., Shrestha R., Jha B. Association of thyroid dysfunction among infertile women visiting infertility center of Om Hospital, Kathmandu, Nepal. Nepal Med. Coll. J. 2011; 13(4): 247-9.
  3. Busnelli A., Somigliana E., Ferrari S., Filippi F., Vannucchi G., Fugazzola L., Fedele L. The long-term impact of controlled ovarian hyper stimulation on thyroid function. Endocr. Pract. 2016; 22(4): 389-95. https://doi.org/10.4158/ EP15933
  4. Перминова С.Г. Бесплодие у женщин с патологией щитовидной железы: принципы диагностики, тактика ведения: автореф. дисс.. д-ра мед. наук. М.; 2010. 49 ^[Perminova S.G. Infertility in women with thyroid disease: principles of diagnosis, management tactics. Author’s abstract dis.. Dr. med sciences. M., 2010. 49 p.(InRuss.)]
  5. Abalovich M., Alcaraz G., Kleiman-Rubinsztein J., Pavlove M.M., Cornelio C., Levalle O., Gutierrez S. The relationship of preconception thyrotropin levels to requirements for increasing the levothyroxine dose during pregnancy in women with primary hypothyroidism. Thyroid. 2010; 20(10): 1175-8. https://doi. org/10.1089/thy.2009.0457
  6. Busnelli A., Vannucchi G., Paffoni A., Faulisi S., Fugazzola L., Fedele L., Somigliana E. Levothyroxine dose adjustment in hypothyroid women achieving pregnancy through IVF. Eur. J. Endocrinol. 2015; 173(4): 417-24. https://doi. org/10.1530/EJE-15-0151
  7. Mintziori G., Goulis D.G., Kolibianakis E.M. Thyroid function and IVF outcome: when to investigate and when to intervene? Curr. Opin. Obstet. Gynecol. 2016; 28(3): 191-7. https://doi.org/10.1097/GCO.0000000000000263.
  8. Busnelli A., Somigliana E., Benaglia L., Leonardi M., Ragni G., Fedele L. In vitro fertilization outcomes in treated hypothyroidism. Thyroid. 2013; 23(10): 1319 https://doi.org/10.1089/thy.2013.0044
  9. Verm a I., Sood R., Juneja S., Kaur S. Prevalence of hypothyroidism in infertile women and evaluation of response of treatment for hypothyroidism on infertility. Int. J. Appl. Basic Med. Res. 2012; 2(1): 17-9.
  10. Перминова С.Г. Бесплодие у женщин с заболеваниями щитовидной железы: принципы диагностики, тактика ведения. Акушерство и гинекология: новости, мнения, обучение. 2013; 2: 18-24. [Perminova S.G. Infertility in women with thyroid diseases: principles of diagnosis, management tactics. Obstetrics and gynecologists: news, opinions, training. 2013; 2: 18-24.(InRuss.)]
  11. Mar aka S., Mwangi R., McCoy R.G., Yao X., Sangaralingham L.R., Singh Ospina N.M. et al. Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US national assessment. BMJ. 2017; 356: i6865. https://doi.org/10.1136/bmj.i6865.
  12. Reh A., Grifo J., Danoff A. What is a normal thyroid-stimulating hormone (TSH) level? Effects of stricter TSH thresholds on pregnancy outcomes after in vitro fertilization. Fertil. Steril. 2010; 94(7): 2920-2. https://doi.org/10.1016/j.fertn-stert. 2010.06.041.

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