Fertility preservation in patients diagnosed with cancer during pregnanc


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Abstract

Aim. To investigate the feasibility of in vitro maturation (IVM) of human oocytes as a fertility-sparing technology in patients diagnosed with cancer during pregnancy. Materials and methods. Ovariectomy was performed during a cesarean section (CS) or elective surgery. Immature oocyte-cumulus complexes were retrieved from the ovarian medulla and underwent 48-72 h in vitro maturation. All mature oocytes were vitrified. The percentage of matured and degenerative oocytes and the number of cryopreserved oocytes were estimated. Results. In all three cases of patients diagnosed with cancer during pregnancy, oocyte-cumulus complexes were obtained. Six, 20, and 24 oocyte-cumulus complexes were isolatedfrom the first, the second, and the third patient, respectively. The oocyte maturation rate was 33.3%, 30.0%, and 54.2%, resulting in vitrification of 2, 6, and 12 oocytes, respectively. Conclusion. Oocyte-cumulus complexes can be successfully isolated from the ovarian medulla after ovary removal during cesarean section or elective surgery. In vitro-matured oocytes can be vitrified or used for in vitro fertilization (IVF) to preserve fertility.

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About the authors

A. O Kirillova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: stasia.kozyreva@gmail.com
Ph.D. (bio.sci.), Senior Researcher at the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

E. S Bunyaeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: esbunyaeva@mail.ru
Ph.D. Student at the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

E. V Koval’skaya

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kovalskaya.evgeniya@gmail.com
Embryologist at the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

N. S Kamaletdinov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: sunsh86@mail.ru
Embryologist at the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

G. N Khabas

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: khabas@list.ru
Ph.D., Head of the Department of Innovative Oncology and Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

M. D Farmakovskaya

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: farmakovskaya@gmail.com
Ph.D., Researcher at the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

E. A Sirotkina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lenasirotkina@gmail.com
Ph.D., Obstetrician Gynecologist at the 2nd Obstetric Physiological Department 4 Oparina str., Moscow, 117997, Russian Federation

N. G Mishieva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nondoc555@mail.ru
MD, Leading Researcher at the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

T. A Nazarenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: t.nazarenko@mail.ru
MD, Professor, Director of the Institute of Reproductive Medicine 4 Oparina str., Moscow, 117997, Russian Federation

A. N Abubakirov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nondoc555@yahoo.com
Ph.D., Head of the 1st Department of Gynecology 4 Oparina str., Moscow, 117997, Russian Federation

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