Application of fiber optic methods and artificial intelligence in ejaculate diagnosis in infertile males in the assisted reproductive technology programs


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Objective. To establish regularities in the transmission spectrum of microstructural waveguides filled with isolated spermatozoa and seminal plasma from males with various disorders of spermatogenesis and, on this basis, to build a neural network that analyzes the spectral characteristics of sperm. Materials and methods. The spectral characteristics of345isolated spermatozoal samples and 209seminal plasma samples were analyzed using photonic crystal waveguides as optical sensors, and an artificial neural network, the prediction accuracy of which was 100%, was built. The patients, whose ejaculate was included in the study, were also surveyed. The main parameters in the questionnaire concerned the factors influencing spermatogenesis. Results. A neural network based on a multilayerperceptron was created, which proved to be effective in analyzing the spectral characteristics of seminal plasma and a sperm fraction. The created neural network of the ejaculate makes it possible to determine the “norm” and “pathology” with the highest accuracy. The use of artificial intelligence to analyze survey results on the male lifestyle proved to be less effective. The rate of correct answers was 88% for the test set of characteristics and 84% for the control set. Nevertheless, the developed neural network can be used for preliminary assessment and prediction of the sperm prof ile based on the results of a patient’s survey. Conclusion. Fiber optic methods in the diagnosis of the ejaculate are perspective and promising. There remains an unresolved issue regarding the absence of both natural and in vitro fertilization pregnancies in the presence of normal sperm counts. The introduction of new tests for seminal plasma and spermatozoa is an urgent task of reproductive medicine; it is especially interesting to use the capabilities of artificial intelligence to assess the fertility of both men and women.

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作者简介

Gennady Sukhikh

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: g_sukhikh@oparina4.ru
M.D., Ph.D., Professor, Director

Julia Skibina

"Nanostructured Glass Technology" Research Production Enterprise, "Structure-Mediated Nanobiophotonics" International Research and Education Center

Email: director@nano-glass.ru
Ph.D. in physics and mathematics, Director

Anastasia Zanishevskaya

"Nanostructured Glass Technology" Research Production Enterprise, "Structure-Mediated Nanobiophotonics" International Research and Education Center

Email: zanishevskayaaa@nano-glass.ru
Senior Research Fellow

Andrey Shuvalov

"Nanostructured Glass Technology" Research Production Enterprise, "Structure-Mediated Nanobiophotonics" International Research and Education Center

Email: zanishevskayaaa@nano-glass.ru
Deputy Head of Research Department

Natalia Yanchuk

"Nanostructured Glass Technology" Research Production Enterprise, "Structure-Mediated Nanobiophotonics" International Research and Education Center

Email: info@nano-glass.ru
Ph.D. in medical sciences, Head

Aleksey Gryaznov

"Nanostructured Glass Technology" Research Production Enterprise, "Structure-Mediated Nanobiophotonics" International Research and Education Center

Email: info@nano-glass.ru
Leading Researcher

Anastasia Sysoeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: a_sysoeva@oparina4.ru
embryologist at the Department of Assisted Reproductive Technologies in the Treatment of Infertility

Nataliya Makarova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: np_makarova@oparina4.ru
Ph.D., Researcher of ART Department

Elvira Valiakhmetova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: ibraeva1988@list.ru
postgraduate student at the ART Department

Elena Kalinina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the Department of Assisted Technologies for the Treatment of Infertility, Scientific Secretary of the Dissertation Council

Pavel Lepilin

"Nanostructured Glass Technology" Research Production Enterprise, "Structure-Mediated Nanobiophotonics" International Research and Education Center

Email: info@nano-glass.ru
Researcher

参考

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