Prenatal ultrasound diagnosis and outcomes of congenital lung malformations: the Center’s 10-year experience with 363 cases


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Objective: To investigate the feasibility of prenatal ultrasound diagnosis and to evaluate the outcomes of fetal congenital lung malformations. Materials and methods: The study included 363pregnant women admitted to the Center from 2010 to 2019, fetal lung malformations were diagnosed prenatally in all the patients. Results: Lung malformations were most frequently diagnosed at 20-22 weeks’ gestation (96.7%). The ultrasound examination revealed the main signs of the disease, namely, an increase in the lung tissue echogenicity (100%), enlarged pathological lung, the presence of cysts (71.9%), and mediastinal shift to the contralateral side. Positive changes in the course of the disease were observed in 77.7% of patients, previously detected signs disappeared completely in 12.3% of them; no changes were noted in 18.2% of cases. Fetal hydrops was identified in 4.4% of fetuses. A total of 271 pregnant women had a delivery at the Center, and 271 children were born alive. The accuracy of ultrasound diagnosis of lung malformations was 92.6%. Surgical treatment was performed in 84.9% of newborns; postoperative mortality was 0.5% (one preterm newborn). Conclusion: Ultrasound examination provides a highly accurate intrauterine diagnosis of lung malformations. Total fetal and child mortality from this pathology was 4.7%, including 4.4% of deaths which occurred preoperatively and 0.3% postoperative deaths.

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Natalya Mashinets

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: natashamashinets@yandex.ru
Ph.D., Senior Researcher at the Department of Functional Diagnostics, Department of Diagnostic Imaging 117997, Russia, Moscow, Ac. Oparin str., 4

Vladimir Demidov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: demydow@yandexru
Dr. Med. Sci., Professor at the Department of Functional Diagnostics, Department of Diagnostic Imagin 117997, Russia, Moscow, Ac. Oparin str., 4

Elena Dorofeeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: dorofey_i@mail.ru
Ph.D., Pediatric Surgeon, Clinical Care Supervisor at the Department of Neonatal Surgery 117997, Russia, Moscow, Ac. Oparin str., 4

Yulia Podurovskaya

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: podurovskaya@yandexru
Ph.D., Department of Neonatal Surgery 117997, Russia, Moscow, Ac. Oparin str., 4

Artem Burov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: burovmd@gmail.ru
Ph.D., Head of clinical work, anesthesiologist-resuscitator of the Department of surgery, reanimation and intensive care of newborns 117997, Russia, Moscow, Ac. Oparin str., 4

Elena Filippova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: fla77@mail.ru
Ph.D., Head of the Department of Ultrasound Diagnostics in Neonatology and Pediatrics 117997, Russia, Moscow, Ac. Oparin str., 4

Alina Kozlova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: av_kozlova@oparina4ru
Physician at the Department of Diagnostic Imaging 117997, Russia, Moscow, Ac. Oparin str., 4

Elena Kulabukhova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: e_kulabuhova@oparina4.ru
Ph.D., Physician at the Department of Diagnostic Imaging 117997, Russia, Moscow, Ac. Oparin str., 4

Alexander Gus

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: aleksandr_gus@mail.ru
r. Med. Sci., Professor, Head of Department of Ultrasound and Functional Diagnostics, Radiology Division 117997, Russia, Moscow, Ac. Oparin str., 4

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