Efficacy of a combined drug containing ferrous fumarate and folic acid in anemia in the second trimester of pregnancy: results of a multicenter study
- 作者: Pavlovich S.V.1, Melikhov O.G.2,3, Khodzhaeva Z.S.1, Muminova K.T.1, Sakalo V.A.1, Gorodnova E.A.1, Abashova E.I.4, Yarmolinskaya M.I.4, Chulkov V.S.5, Nazipova Z.M.6, Savelyeva I.V.7, Andreeva M.D.8, Kudlai Y.V.8, Enkova E.V.9, Zaripova A.S.10
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隶属关系:
- Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Scientific Society “League for Promoting Clinical Trials”
- Institute of Clinical Research
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
- City Center for Hemostatic Pathology
- Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan
- Omsk State Medical University, Ministry of Health of Russia
- Kuban State Medical University, Ministry of Health of Russia
- Voronezh City Clinical Polyclinic No. 1
- Nurmed Medical Center
- 期: 编号 2 (2023)
- 页面: 108-116
- 栏目: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/340781
- DOI: https://doi.org/10.18565/aig.2023.51
- ID: 340781
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详细
Objective: To evaluate the effect of ferrous fumarate/folic acid (FF/FA) on the clinical and laboratory signs of anemia in pregnant women in the second trimester.
Materials and methods: The investigation enrolled 160 women at 14 to 20 weeks’ gestation who were diagnosed with anemia and were prescribed FF/FA.
Results: The use of FF/FA caused a significant improvement in clinical and biochemical blood test results reflecting the severity of anemia: an increase in Hb, Ht, RBC, MCV, MCH, MCHC, serum iron, and ferritin, a decrease in the frequency of microcytosis and serum latent iron-binding capacity. After 3 months of therapy, the total study population displayed an increase in mean values of HgB from 102.0 to 117.0 g/l, ferritin from 46.2 to 55.9 µg/l, serum iron from 12.02 to 20.49 µmol/l. The proportion of patients without anemia was 77% (118/153); that with mild and moderate anemia were 20% (31/153), and 2% (3/153), respectively, which shows a significant improvement compared to that at the start of therapy. In the group with iron deficiency anemia (IDA), (Hb<110 g/l, ferritin<30 µg/l), Hb increased from an average of 103.3 to 109.8 g/l, ferritin from 14.4 to 24.3 µg/l, serum iron from 11.87 to 20.53 µmol/l. After 3 months, mild and moderate IDA was present in 30% (28/93) and 3% (3/93) patients, respectively.
Conclusion. The findings are comparable with international and Russian data and can conclude that FF/FA is an effective and safe way to correct IDA in pregnant women and is suitable for long-term use.
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作者简介
Stanislav Pavlovich
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: s_pavlovich@oparina4.ru
ORCID iD: 0000-0002-1313-7079
PhD, Academic Secretary; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology
俄罗斯联邦, MoscowOleg Melikhov
Scientific Society “League for Promoting Clinical Trials”; Institute of Clinical Research
编辑信件的主要联系方式.
Email: melikhov.oleg@gmail.com
ORCID iD: 0000-0001-9442-7707
PhD, Director; Chairman
俄罗斯联邦, Moscow; MoscowZulfiya Khodzhaeva
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: zkhodjaeva@mail.ru
ORCID iD: 0000-0001-8159-3714
Dr. Med. Sci., Professor, Deputy Director of Obstetrics Institute, Professor at the Department of Obstetrics, Gynecology, Perinatology of the Department of Professional Education
俄罗斯联邦, MoscowKamilla Muminova
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: kamika91@mail.ru
ORCID iD: 0000-0003-2708-4366
PhD, Researcher at the High Risk Pregnancy Department
俄罗斯联邦, MoscowViktoriya Sakalo
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: v_sakalo@oparina4.ru
ORCID iD: 0000-0002-5870-4655
PhD, Junior Researcher at the Department of Pregnancy Pathology, Institute of Obstetrics, doctor at the 1st Obstetric Department of Pregnancy Pathology
俄罗斯联邦, MoscowElena Gorodnova
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: e_gorodnova@oparina4.ru
ORCID iD: 0000-0003-3993-7629
Scopus 作者 ID: 6508176604
PhD, MPH (Master of Public Health), Head of Scientific & Clinical Center
俄罗斯联邦, MoscowElena Abashova
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: abashova@yandex.ru
ORCID iD: 0000-0003-2399-3108
SPIN 代码: 2133-0310
PhD, Senior Researcher, Department of Gynecology and Endocrinology
俄罗斯联邦, Saint PetersburgMaria Yarmolinskaya
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
Professor of RAS, Dr. Med. Sci., Professor, Head of the Department of Gynecology and Endocrinology, Head of Center “Diagnostics and treatment of endometriosis”; Professor at the Department of Obstetrics and Gynecology
俄罗斯联邦, Saint PetersburgVasilii Chulkov
City Center for Hemostatic Pathology
Email: vschulkov@rambler.ru
ORCID iD: 0000-0002-0952-6856
Dr. Med. Sci., Professor at the Department of Faculty Therapy
俄罗斯联邦, ChelyabinskZulfira Nazipova
Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan
Email: zulfira93@mail.ru
ORCID iD: 0009-0002-3591-522X
hematologist
俄罗斯联邦, KazanIrina Savelyeva
Omsk State Medical University, Ministry of Health of Russia
Email: saveljeva_iv_omsk@mail.ru
ORCID iD: 0000-0001-9342-7342
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 1
俄罗斯联邦, OmskMargarita Andreeva
Kuban State Medical University, Ministry of Health of Russia
Email: andreeva_md@mail.ru
ORCID iD: 0000-0002-6524-3965
Dr. Med. Sci., Associate Professor, Professor at the Department of Obstetrics, Gynecology and Perinatology, Faculty of Postgraduate Education
俄罗斯联邦, KrasnodarYulia Kudlai
Kuban State Medical University, Ministry of Health of Russia
Email: kudlai.j@yandex.ru
ORCID iD: 0000-0002-3192-7170
student of the Faculty of Pediatrics
俄罗斯联邦, KrasnodarElena Enkova
Voronezh City Clinical Polyclinic No. 1
Email: enkova@bk.ru
ORCID iD: 0000-0001-8885-1587
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 2
俄罗斯联邦, VoronezhAliya Zaripova
Nurmed Medical Center
Email: zaripovaash@yandex.ru
ORCID iD: 0000-0002-2701-319X
postgraduate student of the Department of Obstetrics and Gynecology named after V.S. Gruzdev; Chief Physician, obstetrician-gynecologist, ultrasound diagnostics doctor
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