Activation of ovarian function in patients with diminished ovarian reserve through administration of extracellular vesicles

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Relevance: Poor response to ovarian stimulation during an IVF program is a pressing issue that limits the effectiveness of assisted reproductive technology (ART). Currently, there are no verified and effective methods in routine clinical practice to improve the success rates of treatment in patients with a poor ovarian response. The use of cell-free therapy as a preparation for IVF/ICSI programs offers a promising alternative to donor oocytes, allowing this group of patients to have genetically related children.

Case report: This article presents three clinical observations that demonstrate the effectiveness of a technique involving the activation of ovarian function through intraovarian administration of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in patients with a history of multiple IVF failures and poor response to ovarian stimulation.

Conclusion: The presented information on the efficacy of MSC-EVs, based on clinical cases of complex and challenging patients with significantly diminished ovarian function, provides hope for the development of a new direction in reproductive medicine based on the use of cellular technologies. Further research is needed to study the intraovarian regulation of folliculogenesis and the mechanisms by which extracellular vesicles influence these processes.

全文:

受限制的访问

作者简介

Yana Martirosyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: marti-yana@yandex.ru
ORCID iD: 0000-0002-9304-4410

Junior Researcher at the F. Paulsen Research and Educational Center for ART

俄罗斯联邦, Moscow

Tatiana Nazarenko

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: t.nazarenko@mail.ru
ORCID iD: 0000-0002-5823-1667

Dr. Med. Sci., Head of the Institute of Reproductive Technologies

俄罗斯联邦, Moscow

Albina Kadaeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: albina.karimovai@mail.ru

PhD student

俄罗斯联邦, Moscow

Kirill Goryunov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: k_gorunov@oparina4.ru
ORCID iD: 0000-0002-8776-7196

PhD (Bio), Researcher at the Laboratory of Cell Technologies

俄罗斯联邦, Moscow

Yulia Shevtsova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: yu_shevtsova@oparina4.ru

Junior Researcher at the Laboratory of Cell Technologies

俄罗斯联邦, Moscow

参考

  1. Abu-Musa A., Haahr T., Humaidan P. Novel physiology and definition of poor ovarian response; Clinical Recommendations. Int. J. Mol. Sci. 2020; 21(6): 2110. https://dx.doi.org/10.3390/ijms21062110.
  2. Giannelou P., Simopoulou M., Grigoriadis S., Makrakis E., Kontogeorgi A., Pantou A. et al. The conundrum of poor ovarian response: from diagnosis to treatment. Diagnostics (Basel). 2020; 10(9): 687. https://dx.doi.org/10.3390/diagnostics10090687.
  3. Seok J., Park H., Choi J.H., Lim J.Y., Kim K.G., Kim G.J. Placenta-derived mesenchymal stem cells restore the ovary function in an ovariectomized rat model via an antioxidant effect. Antioxidants (Basel). 2020; 9(7): 591. https://dx.doi.org/10.3390/antiox9070591.
  4. Jankowska K. Premature ovarian failure. Prz. Menopauzalny. 2017; 16(2): 51-6. https://dx.doi.org/10.5114/pm.2017.68592.
  5. Jaillard S., Bell K., Akloul L., Walton K., McElreavy K., Stocker W.A. et al. New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing. Maturitas. 2020; 141: 9-19. https://dx.doi.org/10.1016/j.maturitas.2020.06.004.
  6. Gersak K., Meden-Vrtovec H., Peterlin B. Fragile X premutation in women with sporadic premature ovarian failure in Slovenia. Hum. Reprod. 2003; 18(8): 1637-40. https://dx.doi.org/10.1093/humrep/deg327.
  7. Zheng Q., Fu X., Jiang J., Zhang N., Zou L., Wang W. et al. Umbilical cord mesenchymal stem cell transplantation prevents chemotherapy-induced ovarian failure via the NGF/TrkA pathway in rats. Biomed. Res. Int. 2019; 2019: 6539294. https://dx.doi.org/10.1155/2019/ 6539294.
  8. Zhang H., Luo Q., Lu X., Yin N., Zhou D., Zhang L. et al. Effects of hPMSCs on granulosa cell apoptosis and AMH expression and their role in the restoration of ovary function in premature ovarian failure mice. Stem Cell Res. Ther. 2018; 9(1): 20. https://dx.doi.org/10.1186/ s13287-017-0745-5.
  9. Liu R., Zhang X., Fan Z., Wang Y., Yao G., Wan X. et al. Human amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice. Stem Cell Res. Ther. 2019; 10(1): 299. https://dx.doi.org/10.1186/s13287-019-1315-9.
  10. Buigues A., Ramírez-Martin N., Martínez J., Pellicer N., Meseguer M., Pellicer A. et al. Systemic changes induced by autologous stem cell ovarian transplant in plasma proteome of women with impaired ovarian reserves. Aging (Albany NY). 2023; 15(24): 14553-73. https://dx.doi.org/10.18632/aging.205400.
  11. Lu Y., Wei Y., Shen X., Tong Y., Lu J., Zhang Y. et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles improve ovarian function in rats with primary ovarian insufficiency by carrying miR-145-5p. J. Reprod. Immunol. 2023; 158: 103971. https://dx.doi.org/10.1016/j.jri.2023.103971.
  12. Cai J.H., Sun Y.T., Bao S. HucMSCs-exosomes containing miR-21 promoted estrogen production in ovarian granulosa cells via LATS1-mediated phosphorylation of LOXL2 and YAP. Gen. Comp. Endocrinol. 2022; 321-322: 114015. https://dx.doi.org/10.1016/j.ygcen.2022.114015.
  13. Sun B., Ma Y., Wang F., Hu L., Sun Y. miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis. Stem Cell Res. Ther. 2019; 10(1): 360. https:// dx.doi.org/10.1186/s13287-019-1442-3.
  14. Xiao G.Y., Cheng C.C., Chiang Y.S., Cheng W.T., Liu I.H., Wu S.C. Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy. Sci. Rep. 2016; 6: 23120. https:// dx.doi.org/10.1038/srep23120.
  15. Zhu W., Yang M., Shang J., Xu Y., Wang Y., Tao Q. et al. MiR-222 inhibits apoptosis in porcine follicular granulosa cells by targeting the THBS1 gene. Anim. Sci. J. 2019; 90(6): 719-27. https://dx.doi.org/10.1111/asj.13208.
  16. Yang Z., Du X., Wang C., Zhang J., Liu C., Li Y. et al. Therapeutic effects of human umbilical cord mesenchymal stem cell-derived microvesicles on premature ovarian insufficiency in mice. Stem Cell Res. Ther. 2019; 10(1): 250. https://dx.doi.org/10.1186/s13287-019-1327-5.
  17. Li Z., Zhang M., Zheng J., Tian Y., Zhang H., Tan Y. et al. Human umbilical cord mesenchymal stem cell-derived exosomes improve ovarian function and proliferation of premature ovarian insufficiency by regulating the Hippo signaling pathway. Front. Endocrinol. (Lausanne). 2021; 12: 711902. https://dx.doi.org/10.3389/fendo.2021.711902.
  18. Мартиросян Я.О., Назаренко Т.А., Кадаева А.И., Краснова В.Г., Бирюкова А.М., Погосян М.Т. Новые подходы к изучению регуляции преимплантационного развития эмбрионов. Акушерство и гинекология. 2023; 6: 29-37. [Martirosyan Ya.O., Nazarenko T.A., Kadaeva A.I., Krasnova V.G., Biryukova A.M., Pogosyan M.T. New approaches to studying the regulation of preimplantation embryonic development. Obstetrics and Gynecology. 2023; (6): 29-37. (in Russian)]. https://dx.doi.org/10.18565/aig.2023.10.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2024
##common.cookie##