Synthesis and Antioxidant Activity (4-(Benzo[d][1,3]-dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylsubstituted Aryloxypropanolamines, Aminoamides and Sulfanilamides
- 作者: Arustamyan Z.S.1, Margaryan R.E.1, Mkryan G.G.1, Aghekyan A.A.1, Panosyan G.A.1, Buniatyan Z.M.1, Muradyan R.E.1
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隶属关系:
- The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
- 期: 卷 60, 编号 1 (2024)
- 页面: 86-93
- 栏目: Articles
- URL: https://journals.eco-vector.com/0514-7492/article/view/672237
- DOI: https://doi.org/10.31857/S0514749224010072
- EDN: https://elibrary.ru/ENFSQA
- ID: 672237
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详细
Alkylation of 3,4-methylenedioxyphenylacetоnitrile with 2,2-dichlorodiethyl ether gave the corresponding nitrile the reduction of which with lithium aluminum hydride isolated (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The interaction of the latter with aryloxymethyloxiranes gave the corresponding 1-((4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamino)-3-aryloxypropan-2-ols. By the reaction of the same amine with chloroacetyl chloride isolated chloroacetamide, the interaction of which with a variety of secondary amines and heterylthiols synthesized the corresponding substituted amino- and sulfanylacetamides - derivatives of (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The antioxidant activity of the obtained compounds was studied.
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作者简介
Zh. Arustamyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
编辑信件的主要联系方式.
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-0541-5315
亚美尼亚, Yerevan
R. Margaryan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-5066-0870
亚美尼亚, Yerevan
G. Mkryan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-9879-9524
亚美尼亚, Yerevan
A. Aghekyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-6151-4951
亚美尼亚, Yerevan
G. Panosyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
亚美尼亚, Yerevan
Zh. Buniatyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-8311-6276
亚美尼亚, Yerevan
R. Muradyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-4110-9454
亚美尼亚, Yerevan
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