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Substituted ureas and their analogues containing framework fragments. I. 1-(4-hydroxyadamanthane-1-yl)-3-(fluo, chlorophenyl)ureas
- Authors: Danilov D.V.1, D’yachenko V.S.1, Zapravdina D.M.1, Ilyina E.S.1, Degtyarenko E.K.1, Burmistrov V.V.1
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Affiliations:
- Volgograd state technical university
- Issue: Vol 60, No 12 (2024)
- Pages: 1195-1203
- Section: Articles
- URL: https://journals.eco-vector.com/0514-7492/article/view/681811
- DOI: https://doi.org/10.31857/S0514749224120029
- EDN: https://elibrary.ru/QEWUPY
- ID: 681811
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Abstract
This work begins a new series of articles devoted to di-, tri- and tetra-substituted urea derivatives and is a continuation of research [1] on modification of the framework fragment in molecules of adamantyl-containing ureas. By the reaction of 1-(4-oxoadamant-1-yl)-3-(halophenyl)ureas with sodium borohydride, a series of 1,3-disubstituted ureas containing a 4-hydroxyadamantan-1-yl radical in their structure was synthesized, with a yield of target products of 55–87%. The synthesized ureas are potential metabolites and promising inhibitors of soluble human epoxide hydrolase (sEH).
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About the authors
D. V. Danilov
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0001-8734-2617
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
V. S. D’yachenko
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-6209-7106
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
D. M. Zapravdina
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-8654-2382
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
E. S. Ilyina
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0009-0005-0475-1113
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
E. K. Degtyarenko
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-7337-4885
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
V. V. Burmistrov
Volgograd state technical university
Author for correspondence.
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-8547-9166
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
References
- Данилов Д.В., Бурмистров В.В., Рассказова Е.В., Бутов Г.М. ЖОрХ., 2020, 56, 870-878. [Danilov D.V., Burmistrov V.V., Rasskazova E.V., Butov G.M., Russ. J. Org. Chem., 2020, 56, 983—989]. doi: 10.1134/S1070428020060032
- Butterworth R.F., Drugs in R&D., 2021, 3, 267—272. doi: 10.1007/s40268-021-00351-6
- Dembitsky V.M., Gloriozova T.A., Poroikov V.V., Biochem. Biophys. Res. Commun., 2020, 529, 1225—1241. doi: 10.1016/j.bbrc.2020.06.123
- Dragomanova S., Andonova V., Pharmacia, 2023, 70, 1057—1066. doi: 10.3897/pharmacia.70.e111593
- Sun C.P., Zhang X.Y., Morisseau C., Hwang S.H., Zhang Z.J., Hammock B.D., Ma X.C., J. Med. Chem., 2020, 64, 184—215. doi: 10.1021/acs.jmedchem.0c01507
- Schmelzer K.R., Kubala L., Newman J.W., Kim I.H., Eiserich J.P., Hammock B.D., Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9772—9777. doi: 10.1073/pnas.0503279102
- Hammock B.D., Kim I., Morisseau C., Watanabe T., Newman J.W. Пат. 0164951 (2005). США.
- Gless R.D., Anandan S.K., Aavula B.R. Междунар. заявка WO 2008 112022.
- Soon K.A., Jin A., Nam S.C., Chang K.H., Tae-Jeong K., Kamsa P., Young J.S., Dong-Oh H., Cheol K.H. Пат. 0062797 (2011) Корея.
- Du F., Sun W., Morisseau C., Hammock B.D., Bao X., Liu Q., Wang C., Zhang T., Yang H., Zhou J., Xiao W., Liu Z., Chen G., Eur. J. Med. Chem. 2021, 223, 113678. doi: 10.1016/j.ejmech.2021.113678
- Jones P.D., Tsai H.J., Do Z.N., Morisseau C., Hammock B.D., Bioorg. Med. Chem. Lett., 2006, 16, 5212-5216. doi: 10.1016/j.bmcl.2006.07.009
- Hwang S.H., Wagner K.M., Morisseau C., Liu J.Y., Dong H., Wecksler A.T., Hammock B.D., J. Med. Chem., 2011, 54, 3037—3050. doi: 10.1021/jm2001376
- Huang S.X., Cao B., Morisseau C., Jin Y., Hammock B.D., Long Y.Q., Med. Chem. Commun., 2012, 3, 379—384. doi: 10.1039/C2MD00288D
- Бурмистров В.В., Питушкин Д.А., Васипов В.В., Дьяченко В.С., Бутов Г.М., ХГС, 2019, 55, 619-622. [Burmistrov V.V., Pitushkin D.А., Vasipov V.V., D’yachenko V.S., Butov G.M., Chem. Heterocycl. Compd., 55, 619—622.] doi: 10.1007/s10593-019-02507-4
- Burmistrov V., Morisseau C., D'yachenko V., Karlov D., Butov G.M., Hammock B.D., Bioorg. Med. Chem. Lett., 2019, 30, 126908. doi: 10.1016/j.bmcl.2019.126908
- Burmistrov V., Morisseau C., Danilov D., Harris T.R., Dalinger I., Vatsadze I., Shkineva T., Butov G.M., Hammock B.D., Bioorg. Med. Chem. Lett., 2015, 25, 5514—5519. doi: 10.1016/j.bmcl.2015.10.066
- Бурмистров В.В., Данилов Д.В., Дьяченко В.С., Рассказова Е.В., Бутов Г.М., ЖОрХ., 2020, 56, 672-678. [Burmistrov V.V., Danilov D.V., D'yachenko V.S., Rasskazova E.V., Butov G.M. Russ. J. Org. Chem., 2020, 56, 735—740]. doi: 10.1134/S1070428020050024
- Liu J.Y., Tsai H.J., Morisseau C., Lango J., Hwang S.H., Watanabe T., Kim I.H., Hammock B.D. Biochem. Pharmacol., 2015, 98, 718—731. doi: 10.1016/j.bcp.2015.10.013
- Hwang S.H., Wecksler A.T., Zhang G., Morisseau C., Nguyen L.V., Fu S.H., Hammock B.D., Bioorg. Med. Chem. Lett., 2013, 23, 3732—3737. doi: 10.1016/j.bmcl.2013.05.011
- Inceoglu B., Jinks S.L., Ulu A., Hegedus C.M., Georgi K., Schmelzer K.R., Wagner,K., Jones P.D., Morisseau C., Hammock B.D. Proc. Natl. Acad. Sci., 2008, 105, 18901—18906. doi: 10.1073/pnas.0809765105
- Данилов Д.В., Бурмистров В.В., Кузнецов Я.П., Дьяченко В.С., Е.В. Рассказова, Бутов Г.М., ЖОрХ, 2021, 57, 339-351. [Danilov D.V., Burmistrov V.V., Kuznetsov Y.P., D'yachenko V.S., Rasskazova E.V., Butov G.M., Russ. J. Org. Chem., 2021, 57, 327—337]. doi: 10.1134/S1070428021030027
- Gladkikh B.P., D’yachenko V.S., Danilov D.V., Matiukhina A.K., Burmistrov V.V. Butov G.M., Russ. J. Org. Chem., 2023, 59, 2138—2146. doi: 10.1134/S1070428023120114
- Гладких Б.П., Данилов Д.В., Дьяченко В.С., Бурмистров В.В., Бутов Г.М., Новаков И.А., Изв. АН. Сер. хим., 2022, 9, 1998—2005. [Gladkikh B.P., Danilov D.V., D’yachenko V.S., Burmistrov V.V., Butov G.M., Novakov I.A., Russ. Chem. Bull., 2022, 71, 1998—2005. doi: 10.1007/s11172-022-3620-1.
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