Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1 Н -imidazole-5-carboxylates with Benzyl Halides

Polina A. Nikitina; Никитина Полина Андреевна; Irina A. Oskina; Оськина Ирина Александровна; Elena B. Nikolaenkova; Николаенкова Елена Борисовна; Ekaterina A. Kulikova; Куликова Екатерина Андреевна; Vladimir S. Miroshnikov; Мирошников Владимир Сергеевич; Valery P. Perevalov; Перевалов Валерий Павлович; Alexey Ya. Tikhonov; Тихонов Алексей Яковлевич

doi:10.31857/S0514749225040144

Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1Н-imidazole-5-carboxylates with Benzyl Halides

作者: Nikitina P.A.¹, Oskina I.A.², Nikolaenkova E.B.², Kulikova E.A.¹, Miroshnikov V.S.¹, Perevalov V.P.¹, Tikhonov A.Y.²
隶属关系:
1. Mendeleev University of Chemical Technology of Russia
2. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS
期: 卷 61, 编号 4 (2025)
页面: 475-483
栏目: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://journals.eco-vector.com/0514-7492/article/view/689699
DOI: https://doi.org/10.31857/S0514749225040144
EDN: https://elibrary.ru/SEOHNP
ID: 689699

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详细

Alkylation of ethyl 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with substituted benzyl halides led to the selective formation of O-alkoxy derivatives. Products of N-alkylation (1-alkylimidazole 3-oxides) could be obtained by condensation reaction from acyclic starting compounds. If a 2-hydroxyphenyl moiety was present in position 2 of imidazole ring, then monoalkylation proceeded selectively at hydroxy group of the nitrogen atom of heterocycle.

关键词

alkylation, 1-hydroxyimidazoles, 1-benzylimidazoles, imidazole 3-oxides, benzyl halides

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作者简介

Polina Nikitina

Mendeleev University of Chemical Technology of Russia

编辑信件的主要联系方式.
Email: polinandrevna@yandex.ru
ORCID iD: 0000-0003-1542-5565
俄罗斯联邦, 9, Miusskaya Sqr., Moscow, 125047

Irina Oskina

Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0001-5788-0182
俄罗斯联邦, 9, Ac. Lavrentyev Ave., Novosibirsk, 630090

Elena Nikolaenkova

Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS

Email: polinandrevna@yandex.ru
ORCID iD: 0009-0000-5034-8513
俄罗斯联邦, 9, Ac. Lavrentyev Ave., Novosibirsk, 630090

Ekaterina Kulikova

Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
ORCID iD: 0009-0009-2311-395X
俄罗斯联邦, 9, Miusskaya Sqr., Moscow, 125047

Vladimir Miroshnikov

Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0003-3815-7479
俄罗斯联邦, 9, Miusskaya Sqr., Moscow, 125047

Valery Perevalov

Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0002-3980-6496
俄罗斯联邦, 9, Miusskaya Sqr., Moscow, 125047

Alexey Tikhonov

Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0002-6391-4366
俄罗斯联邦, 9, Ac. Lavrentyev Ave., Novosibirsk, 630090

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