Synthesis of Spiro[indole-3,2′-pyrrole]triones by the Reaction of Pyrrolobenzoxazepinetriones with Enaminoketone

A. A. Maslivets; Масливец Анна Андреевна; M. V. Dmitriev; Дмитриев Максим Викторович; A. N. Maslivets; Масливец Андрей Николаевич

doi:10.31857/S0514749224020033

Synthesis of Spiro[indole-3,2′-pyrrole]triones by the Reaction of Pyrrolobenzoxazepinetriones with Enaminoketone

Authors: Maslivets A.A.¹, Dmitriev M.V.¹, Maslivets A.N.¹
Affiliations:
1. Perm State University
Issue: Vol 60, No 2-3 (2024)
Pages: 162–166
Section: Articles
URL: https://journals.eco-vector.com/0514-7492/article/view/672198
DOI: https://doi.org/10.31857/S0514749224020033
EDN: https://elibrary.ru/EKHZXE
ID: 672198

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Abstract

The reaction of 3-aroylpyrrolo[1,2-a][4,1]benzoxazepin-1,2,4-triones with 3-cyclohexylamino-5,5-dimethylcyclohex-2-en-1-one leads to the formation of 3′-(4-aroyl)-4′-hydroxy-1′-(2-(hydroxymethyl)phenyl)-6,6-dimethyl-1-cyclohexyl-6,7-dihydrospiro[indole-3,2′-pyrrole]-2,4,5′(1H,1′H,5H)-triones. A new scheme for the interaction of 3-aroylpyrrolo[1,2-а][4,1]benzoxazepine-1,2,4-triones with N-substituted enaminoketones leading to the formation of derivatives of the difficult-to-reach heterocyclic systems of spiro[indole-3,2′-pyrrole]triones is described.

Keywords

hetero[e]pyrrole-2,3-diones, 3-aroylpyrrolo[1,2-а][4,1]benzoxazepin-1,2,4-triones, spiro[indoline-3,2′-pyrrole]ones, enaminoketone

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References

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2. Fig. General view of the molecule of compound 2b according to X-ray diffraction data. The dotted line shows the atoms and bonds of the minor conformer.