The CYP443C1 (CYP74 clan) cytochrome of sea anemone Nematostella vectensis - the first Metazoan enzyme possessing hydroperoxide lyase / epoxyalcohol synthase activity

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Abstract

A novel CYP74 clan gene CYP443C1 of the starlet sea anemone (Nematostella vectensis, Cnidaria) has been cloned, and the properties of the corresponding recombinant protein have been studied. Depending on the substrate, CYP443C1 exhibited double function hydroperoxide lyase/epoxyalcohol synthase activity.

About the authors

S. S. Gorina

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences

Author for correspondence.
Email: gsvetlana87@gmail.com
Russian Federation, 2/31, Lobachevskiy street, Kazan, Tatarstan, 420111

Y. Y. Toporkova

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences

Email: gsvetlana87@gmail.com
Russian Federation, 2/31, Lobachevskiy street, Kazan, Tatarstan, 420111

L. S. Mukhtarova

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences

Email: gsvetlana87@gmail.com
Russian Federation, 2/31, Lobachevskiy street, Kazan, Tatarstan, 420111

A. N. Grechkin

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences

Email: gsvetlana87@gmail.com

Academician of the Russian Academy of Sciences

Russian Federation, 2/31, Lobachevskiy street, Kazan, Tatarstan, 420111

References

  1. Gerwick W.H., Moghaddam M., Hamberg M. // Arch. Biochem. Biophys. 1991 V. 290 P. 436-444.
  2. Gabbs M., Leng S., Devassy J.G., Monirujjaman M., Aukema H.M. // Adv. Nutr. 2015. V. 6. P. 513-540.
  3. Stumpe M., Feussner I. // Phytochem. Rev. 2005. P. 347-357.
  4. Koeduka T., Ishizaki K., Mwenda C.M., Hori K., Sasaki-Sekimoto Y., Ohta H., Kohchi T., Matsui K. // Planta. 2015. V. 242. P. 1175-1186.
  5. Toporkova Y.Y., Fatykhova V.S., Gogolev Y.V., Khairutdinov B.I., Mukhtarova L.S., Grechkin A.N. // Biochim. Biophys. Acta. 2017. V. 1761. P. 1419-1428. Lee D.-S., Nioche P., Hamberg M., Raman C.S. // Nature. 2008. V. 455, P. 363-370.
  6. Toporkova Y.Y., Gorina S.S., Mukhitova F.K., Hamberg M., Ilyina T.M., Mukhtarova L.S., Grechkin A.N. // Biochim. Biophys. Acta. 2017. V. 1862. P. 1099-1109.
  7. Mukhtarova L.S., Mukhitova F.K., Gogolev Y.V., Grechkin A.N. // Phytochemistry. 2011. V. 72. P. 356-364.
  8. Toporkova Y.Y., Gorina S.S., Bessolitsyna E.K., Smirnova E.O., Fatykhova V.S., Brühlmann F., Ilyina T.M., Mukhtarova L.S., Grechkin A.N. // Biochim. Biophys. Acta. 2018. V. 1863. P. 369-378.
  9. Grechkin A.N., Brühlmann F., Mukhtarova L.S., Gogolev Y.V., Hamberg M. // Biochim. Biophys. Acta. 2006. V. 1761. P. 1419-1428.
  10. Teder T., Lõhelaid H., Boeglin W.E., Calcutt W.M., Brash A.R., Samel N. // J Biol Chem. 2015. V. 290. P. 19 823-19 832.

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