Email this article The expression level of S100A4 protein affects the migration activity of breast cancer cells
- Authors: Dukhanina E.A.1, Portseva T.N.1, Kotnova A.P.1, Pankratova E.V.1, Georgieva S.G.1
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Affiliations:
- Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- Issue: Vol 485, No 2 (2019)
- Pages: 226-228
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12857
- DOI: https://doi.org/10.31857/S0869-56524852226-228
- ID: 12857
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Abstract
Reduced expression of S100A4 protein metastasis marker in tripletnegative breast cancer cells (BC) MDA MB 231 leads to a decrease in the migratory ability of cells and increases the sensitivity of modified cells to docetaxel therapy. Cells capable of migration differ from immobile cells in the S100A4 protein content inside the cell, and this difference is preserved after the cells are treated with agents that lower the intracellular level of S100A4. The presence of exogenous protein S100A4 in the culture medium reduces the protein content in breast cancer cells. The results of the research indicate that the ability of BC cells to migrate depends on the concentration of S100A4 protein inside the cell.
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About the authors
E. A. Dukhanina
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Author for correspondence.
Email: tanjnil@mail.ru
Russian Federation, Moscow
T. N. Portseva
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: tanjnil@mail.ru
Russian Federation, Moscow
A. P. Kotnova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: tanjnil@mail.ru
Russian Federation, Moscow
E. V. Pankratova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: tanjnil@mail.ru
Russian Federation, Moscow
S. G. Georgieva
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: tanjnil@mail.ru
corresponding member of the RAS
Russian Federation, MoscowReferences
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