Tribochemical Component of Oxidative Stress Development when Implantating of Artificial Joints. Part 2. Oxidative and Antiproliferative Effect of Wear Debris of Orthopedic Materials

Abstract


Using modeling reaction with constant production of metal radical-generated wear debris it was determined increasing intensification of oxidative processes. Generated free radicals enabled to oxidize polymeric component of endoprostheses. Radical-generated wear debris significantly decreased the proliferative ability of human osteogenic cells. Inert ceramics particles showed antiprolifirative effect only in their high concentration. Those particles prevented growth
of osteogenic cells. Worsening in mechanical properties of polymeric implant components and disturbance of bone remodeling under radical-generated wear debris may be one of the causes of further development of implant loosening and its instability.

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Copyright (c) 2010 Bulgakov V.G., Il'ina V.K., Gavryushenko N.S., Shal'nev A.N., Omel'yanenko N.P., Bulgakov V.G., Il'ina V.K., Gavryushenko N.S., Shal'nev A.N., Omel'yanenko N.P.

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