NEUROPROTECTIVE EFFECT OF ENDACANNABINOID N-ARACHIDONOYLDOPAMINE IN ACUTE HYPOBARIC HYPOXIA



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Abstract

The effect of the endogenous cannabinoid N-arachi-donoyldopamin (AA-DA) in acute hypobaric hypoxia in mice was studied. The lifetime of the animals at the height, survival, changes in locomotor activity with the test «open field» and the long-term memory with test «Morris water maze» were evaluated. It was revealed that injection of AA-DA significantly increased survival animals and long-term memory in remote period of acute hypoxia. Neuroprotective effect of AA-DA was shown.

About the authors

Elena V Mitroshina

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

Email: mitroshinae@list.ru
1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

Maria V Vedunova

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

Andrei A Mironov

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

Tatyana A Saharnova

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

Alexei S Pimashkin

The N.I. Lobachevsky Nizhny Novgorod State University

The N.I. Lobachevsky Nizhny Novgorod State University

Mikhail Y Bobrov

1) Institute of biochemistry, named after academicians М.М. Shemyakin and Yu. A. Оvchinnikov, RAS; 2) State Institution Scientific Neurology centre of RAMS

1) Institute of biochemistry, named after academicians М.М. Shemyakin and Yu. A. Оvchinnikov, RAS; 2) State Institution Scientific Neurology centre of RAMS

Leonid G Khaspeckov

State Institution Scientific Neurology centre of RAMS

State Institution Scientific Neurology centre of RAMS

Irina V Mukhin

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

References

  1. Бобров М.Ю., Генрихс Е.Е., Барсков И.В. и др. Нейропротекторный эффект модуляторов эндогенной каннабиноидной системы при экспериментальной церебральной ишемии / В кн.: Рецепторы и внутриклеточная сигнализация. - 2011, Пущино. - Т. 1. - С. 94-98.
  2. Методические рекомендации по экспериментальному изучению препаратов, предлагаемых для клинического изучения в качестве антигипоксических средств. - М., 1990. - 18 с.
  3. Хаспеков Л.Г., Бобров М.Ю. Эндогенная канна-биноидная система и ее защитная роль // Нейрохимия. - 2006. - Т. 23, №2. - С. 85-105.
  4. Bisogno T., Melck D., Bobrov M. Yuю et al. N-acyl-dopamines : novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo // Biochem. J. - 2000. - Vol. 351. - P. 817-824.
  5. Bobrov M.Y., Lizhin A.A., Andrianova E.L. et al. Antioxidant and neuroprotective properties of N-arachido-noyldopamine // Neurosci. Lett. - 2008. - Vol. 431, №1. - P. 6-11.
  6. D'Hooge R., De Deyn P.P. Application for the Morris water maze in the study of learning and memory // Brain Res. Rev. - 2001. - №36. - Р. 60-90.
  7. Herkenham M., Lynn A.B., Johnson M.R. et al. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study // J. Neurosci. - 1991. - Vol. 11. - P.563-568.
  8. Kano M., Ohno-Shosaku T., Hashimotodani Y. et al. Endocannabinoid-mediated control of synaptic transmission // Physiol Rev. - 2009. - Vol. 89, №1. - Р. 309-380.
  9. Mackie K. Distribution of cannabinoid receptors in the central and peripheral nervous system // Handbook of experi-mental pharmacology. - 2005. - Vol. 168. - P. 299-325.
  10. Mechoulam R., Panikashvili D and Shohami E. Cannabinoids and brain injury: therapeutic implications // TRENDS in Molecular Medicine. - 2002. - Vol.8, №2. - P. 58-61.
  11. Morgan N.H., Stanford I.M., Woodhall G.L. Functional CB2 type cannabinoid receptors at CNS synapses // Neuropharmacology. - 2009. - Vol. 57, №4. - P. 356-368.
  12. Morris R.G.M., Garrud P., O'Keefe J. Place navigation impaired in rats with hippocampal lesions // Nature. - 1982. - №297. - Р. 681-683.
  13. Panikashvili D., Simeonidou C., Ben-Shabat S. et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury // Nature. - 2001. - Vol. 413. - P. 527-531.
  14. Pertwee R.G. Cannabinoid pharmacology: the first 66 years // British Journal of Pharmacology. - 2006. - Vol. 147. - P. S163-S171.
  15. Riedel G., Davies S.N. Cannabinoid function in learning, memory and plasticity / In: Cannabinoids. Handbook of Experi-mental Pharmacology. - 2005. - Vol. 168. - P 445-477.
  16. Schomacher M., Mьller H. D., Sommer C. et al. Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia // Brain Research. - 2008. - Vol. 1240. - P. 213-220.
  17. Szabo B. Pharmacology of cannabinoid receptors // Biotrend reviews. - 2008. - №2. - P. 1-13.
  18. Szabo B., Schlicker E. Effects of Cannabinoids on Neurotransmission / In: Cannabinoids. Handbook of Experimental Pharmacology. - 2005. - Vol. 168. - P. 327-365.

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Copyright (c) 2012 Mitroshina E.V., Vedunova M.V., Mironov A.A., Saharnova T.A., Pimashkin A.S., Bobrov M.Y., Khaspeckov L.G., Mukhin I.V.

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