Vol XLIV, No 1 (2012)

With the purpose of detection an endothelium dysfunction role in the hypertensive encephalopathy (HE) progressing, 209 HE I-HE III patients were examined. The HE pathogenetic subtypes were detected: the ones with constitutional phlebopathy (CPP) and HE pathogenetic subtypes without it (NP). A cliniconeurologic investigation, diurnal arterial blood pressure monitoring was held, with ultrasonic imaging an endothelium function and cerebral haemodynamics research was carried out. It was established, that the endothelium function is disordered in the initial disease stage to an equal degree under various HE subtypes, the rates of diurnal index and arterial blood pressure rising speed in HE patients differ from control rates. The endothelium function in all patient groups is influenced by smoking; by arterial blood pressure variability in CPP group; also by age and arterial blood pressure load in NP patients. Pathologic active conditions, progressing on all the cerebral vascular system structural-functional levels under HE, were analyzed; an endothelium function participation in the pathologic active conditions progressing was shown.

The effect of the endogenous cannabinoid N-arachi-donoyldopamin (AA-DA) in acute hypobaric hypoxia in mice was studied. The lifetime of the animals at the height, survival, changes in locomotor activity with the test «open field» and the long-term memory with test «Morris water maze» were evaluated. It was revealed that injection of AA-DA significantly increased survival animals and long-term memory in remote period of acute hypoxia. Neuroprotective effect of AA-DA was shown.

The paper presents the results of a study of non-psychotic psychiatric disorders frequency in 192 patients with rheumatoid arthritis with different clinical, social and psychological characteristics. The relationship of non-psychotic mental disorder is not so much the level of clinical characteristics of the rheumatoid arthritis (the activity, duration of morning stiffness, number of tender and swollen joints, radiographic stage, the presence of extra-articular manifestations), but its effects - dysfunction of the joints, duration of rheumatoid arthritis and social factors as well as personal stock of patients

We studied the dynamics of circulatory disease mortality in Arkhangelsk, Vologda, Murmansk region, its association with alcoholization. Using ARIMA method for the period 1975-2008 the inverse associations between alcohol poisoning mortality and mortality from myocardial infarction, and positive relationship with other ischemic heart disease have been found. Alcohol probably plays different role in the genesis of cardiovascular mortality.

Based on the results of the pilot study there was examined the relationship of anticipation abilities, psychological defense mechanisms, coping, and individual psychological characteristics of personality in a comparative perspective of groups of parents of children with chronic or acute diseases. It is concluded that the complex coping behavior of parents of children with chronic diseases, differs from a group of parents of children with acute illnesses.

In the review the data about barriers, which the female IDU's face when receiving medical aid, are cited. Gender specificity of formation of drug dependence, prevalence of drug addiction at women in Russia, stigmatization of patients is described.

There were analyzed the latest developments in direct, not mediated by transplantation transfected delivery cells of therapeutic genes to stimulate posttraumatic neurogeneration. We present results of their research on two experimental models of neurotrauma. Direct one-time delivery to the damaged area of therapeutic cloning of human genes vegf and fgf2 using non-viral vectors improves post-traumatic regeneration of peripheral nerve and spinal cord. Direct injection of plasmid DNA directly into the damaged area is a little less efficient delivery of the same therapeutic genes to the cellular carriers in their immediate area of transplantation in contusion spinal cord injury, and by some measures even surpasses it. Prospects for improving the efficiency of direct gene therapy is associated with the use of synthetic platform based on biocompatible and biosoluble materials.