MODERN CONCEPTS OF BIOMARKERS IN PARKINSON’S DISEASE

Abstract


This review presents the current understanding of the pathogenesis of Parkinson’s disease with the participation of different molecules (mitochondrial dysfunction, metabolic enzymes, enzymes from lysosomes, endosomes and ER, factors of the immune response and neuroinflammation, factors of the oxidative stress and proteasome degradation of proteins, chaperones, regulators of physiological and pathological processes, structural and transport proteins, molecules of signal transduction, glial proteins and proteins of synaptic vesicles, neurotoxic proteins, molecules of neuron-glia communication), which may be the genomic and/or proteomic biomarkers of this type of neurodegeneration.

Full Text

СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МОЛЕКУЛАХ-МАРКЕРАХ ПРИ БОЛЕЗНИ ПАРКИНСОНА

About the authors

Nataliya A Malinovskaya

Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky

Email: reg.kgmu@gmail.com
660022, Krasnoyarsk, Partizana Zheleznyaka 1
Department of Biochemistry with courses Medical, Pharmaceutical and Toxicological Chemistry

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