BASIC MECHSNISMS OF PERIPHERAL NOCICEPTION

Abstract


In this review we present basic data on the biological role of different types of pain, and how pain is generated in the peripheral part of the nociceptive system. Many issues of peripheral nociception, which have a specific regional character, become clear only recently, thanks to new molecular and cellular technologies. Uncovering the molecular nature of pain transducers allows us to search now for specific analgesics and this gives us a hope that these new agents will reach the stage of wide clinical applications for the treatment of acute and chronic pain. This review precedes a series of other articles devoted to pain studies to be published in this and in the subsequent issues of the journal Nevrologicheskii Vestnik.

About the authors

Ksenia S Koroleva

Kazan (Volga Region) Federal University

Email: kseniya.ks29061991@yandex.ru
420008, Kazan, The Kremlin street, 18
Institute of Basic Medicine and Biology

Raisa R Giniatullina

University of Eastern Finland

70211, Kuopio, POBox 1627 / Neulaniementie 2
AI Virtanen Institute

Rashid Askhatovich Giniatullin

Email: Rashid.Giniatullin@uef.fi

References

  1. Гиниатуллин Р.А. Нейрофизиологические механизмы мигрени и новые принципы патогенетического лечения // Казанский мед. ж. 2011. №5. С. 728-735
  2. Cox J.J., Reimann F., Nicholas A.K. et al. An SCN9A channelopathy causes congenital inability to experience pain // Nature. 2006. Vol 444
  3. Cox J.J., Sheynin J., Shorer Z. et al. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations // Hum. Mutat. 2010. Vol. 31
  4. Burnstock G. Purinergic mechanisms and pain-Anupdate // Eur. J. Pharmacol. 2013
  5. Chen C.C., Akopian A.N., Sivilotti L. et al. A P2Xpurinoceptor expressed by a subset of sensory neurons // Nature.1995. Vol. 377(6548). P. 428-431
  6. Du J., Reznikov L.R., Price M.P. Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala // PNAS. 2014. Vol. 111 (24). P. 8961-8966
  7. Gauriau C., Bernard J.F. Pain pathways and parabrachial circuits in the rat // Exp Physiol. 2002. Vol. 87(2). P. 251-258
  8. Jarvis M.F., Burgard E.C., McGaraughty S. et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat // PNAS 2002. Vol. 99 (26). P. 17179-17184
  9. Julius D., Basbaum A.I. Molecular mechanisms of nociception // Nature. 2001. Vol. 13. P. 203-210
  10. McGaraughty S., Wismer C.T., Zhu C.Z. et al. Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration// Br. J. Pharmacol. 2003. Vol.140(8). P.1381-1388
  11. Naves L.A., McCleskey E.W. An acid-sensing ionchannel that detects ischemic pain // Braz J. Med. Biol. Res.2005. Vol. 38(11). P. 1561-1569
  12. Park T.J., Lu Y., Jüttner R. et al. Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber) // PLoS Biol. 2008. Vol 6(1)
  13. Qiu F., Qiu C.Y., Liu Y.Q. Potentiation of acid-sensing ion channel activity by the activation of 5-HT receptors in rat dorsal root ganglion neurons // Neuropharmacology. 2012. Vol. 63(3). P. 494-500
  14. Rowe A.H., Xiao Y., Rowe M.P. et al. Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin // Science. 2013. Vol. 25; 342(6157). P. 441-446
  15. Roberson D., Binshtok A., Blasl F. et al. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review // British Journal of Pharmacology. 2011. Vol. 164. P. 48-58
  16. Schaible H.G. Peripheral and central mechanisms ofpain generation // Handb Exp. Pharmacol. 2007. Vol. 177. P. 3-28
  17. Schueler M., Messlinger K., Dux M. Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache // Pain. 2013. Vol. 154(9) P. 1622-1631
  18. Souslova V., Cesare P., Ding Y. et al. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors // Nature. 2000. Vol. 407(6807). P. 1015-1017

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Copyright (c) 2014 Koroleva K.S., Giniatullina R.R., Giniatullin R.A.

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