BASIC MECHSNISMS OF PERIPHERAL NOCICEPTION
- Authors: Koroleva K.S1, Giniatullina R.R2, Giniatullin R.A.3
-
Affiliations:
- Kazan (Volga Region) Federal University
- University of Eastern Finland
- Issue: Vol XLVI, No 3 (2014)
- Pages: 22-27
- Section: Articles
- Submitted: 20.06.2019
- Published: 15.09.2014
- URL: https://journals.eco-vector.com/1027-4898/article/view/13856
- DOI: https://doi.org/10.17816/nb13856
- ID: 13856
Cite item
Full Text
Abstract
In this review we present basic data on the biological role of different types of pain, and how pain is generated in the peripheral part of the nociceptive system. Many issues of peripheral nociception, which have a specific regional character, become clear only recently, thanks to new molecular and cellular technologies. Uncovering the molecular nature of pain transducers allows us to search now for specific analgesics and this gives us a hope that these new agents will reach the stage of wide clinical applications for the treatment of acute and chronic pain. This review precedes a series of other articles devoted to pain studies to be published in this and in the subsequent issues of the journal Nevrologicheskii Vestnik.
Keywords
About the authors
Ksenia S Koroleva
Kazan (Volga Region) Federal University
Email: kseniya.ks29061991@yandex.ru
Institute of Basic Medicine and Biology 420008, Kazan, The Kremlin street, 18
Raisa R Giniatullina
University of Eastern FinlandAI Virtanen Institute 70211, Kuopio, POBox 1627 / Neulaniementie 2
Rashid Askhatovich Giniatullin
Email: Rashid.Giniatullin@uef.fi
References
- Гиниатуллин Р.А. Нейрофизиологические механизмы мигрени и новые принципы патогенетического лечения // Казанский мед. ж. 2011. №5. С. 728-735
- Cox J.J., Reimann F., Nicholas A.K. et al. An SCN9A channelopathy causes congenital inability to experience pain // Nature. 2006. Vol 444
- Cox J.J., Sheynin J., Shorer Z. et al. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations // Hum. Mutat. 2010. Vol. 31
- Burnstock G. Purinergic mechanisms and pain-Anupdate // Eur. J. Pharmacol. 2013
- Chen C.C., Akopian A.N., Sivilotti L. et al. A P2Xpurinoceptor expressed by a subset of sensory neurons // Nature.1995. Vol. 377(6548). P. 428-431
- Du J., Reznikov L.R., Price M.P. Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala // PNAS. 2014. Vol. 111 (24). P. 8961-8966
- Gauriau C., Bernard J.F. Pain pathways and parabrachial circuits in the rat // Exp Physiol. 2002. Vol. 87(2). P. 251-258
- Jarvis M.F., Burgard E.C., McGaraughty S. et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat // PNAS 2002. Vol. 99 (26). P. 17179-17184
- Julius D., Basbaum A.I. Molecular mechanisms of nociception // Nature. 2001. Vol. 13. P. 203-210
- McGaraughty S., Wismer C.T., Zhu C.Z. et al. Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration// Br. J. Pharmacol. 2003. Vol.140(8). P.1381-1388
- Naves L.A., McCleskey E.W. An acid-sensing ionchannel that detects ischemic pain // Braz J. Med. Biol. Res.2005. Vol. 38(11). P. 1561-1569
- Park T.J., Lu Y., Jüttner R. et al. Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber) // PLoS Biol. 2008. Vol 6(1)
- Qiu F., Qiu C.Y., Liu Y.Q. Potentiation of acid-sensing ion channel activity by the activation of 5-HT receptors in rat dorsal root ganglion neurons // Neuropharmacology. 2012. Vol. 63(3). P. 494-500
- Rowe A.H., Xiao Y., Rowe M.P. et al. Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin // Science. 2013. Vol. 25; 342(6157). P. 441-446
- Roberson D., Binshtok A., Blasl F. et al. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review // British Journal of Pharmacology. 2011. Vol. 164. P. 48-58
- Schaible H.G. Peripheral and central mechanisms ofpain generation // Handb Exp. Pharmacol. 2007. Vol. 177. P. 3-28
- Schueler M., Messlinger K., Dux M. Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache // Pain. 2013. Vol. 154(9) P. 1622-1631
- Souslova V., Cesare P., Ding Y. et al. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors // Nature. 2000. Vol. 407(6807). P. 1015-1017