APATHETIC DEPRESSION - THE CLINICAL AND NEUROPHYSIOLOGICAL ANALYSIS



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Abstract

Studying for the first time of the apathetic depression revealed at late age, determination of its interrelation with cognitive violations and neuroanatomic changes was the purpose of this work. It was revealed that existence of an apathetic component in a clinical picture of a depression reflects a tendency to increase of depression severity, deterioration in cognitive functioning of patients, predetermines essential decrease in all indexes of social functioning and correlates with increase of vascular changes of brain.

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About the authors

Alla S Avedisova

V. Serbsky Federal medical research centre for psychiatry and narcology

109559, Russia, Moscow, Kropotkinskiy per., 23

Ksenia V Zakharova

V. Serbsky Federal medical research centre for psychiatry and narcology

Email: ksushkaa@bk.ru
109559, Russia, Moscow, Kropotkinskiy per., 23

Vladislav V Gaskin

V. Serbsky Federal medical research centre for psychiatry and narcology

109559, Russia, Moscow, Kropotkinskiy per., 23

Irina S Samotaeva

V. Serbsky Federal medical research centre for psychiatry and narcology

109559, Russia, Moscow, Kropotkinskiy per., 23

Inna A Arkusha

V. Serbsky Federal medical research centre for psychiatry and narcology

109559, Russia, Moscow, Kropotkinskiy per., 23

References

  1. Петрова Е.А., Поневежская Е.В., Савина М.А., Скворцова В.И. Клинические особенности постинсультной апатии // Журнал неврологии и психиатрии им. С.С. Корсакова. 2012. № 12, вып. 2. Инсульт. С. 15-19.
  2. Apostolova L.G. et al. Structural correlates of apathy in Alzheimer’s disease // Dementia and geriatric cognitive disorders. 2007. Vol. 2. P. 91-97.
  3. Bruen P.D. et al. Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer’s disease // Brain. 2008. Vol. 9. P. 2455-2463.
  4. Fazekas F. et al. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging // American Journal of Neuroradiology. 1987. Vol. 3. P. 421-426.
  5. Grool A.M. et al. Structural MRI correlates of apathy symptoms in older persons without dementia AGES-Reykjavik Study // Neurology. 2014. Vol. 18. P. 1628-1635.
  6. Kostić V. S., Filippi M. Neuroanatomical correlates of depression and apathy in Parkinson’s disease: magnetic resonance imaging studies // Journal of the neurological sciences. 2011. Vol. 1. P. 61-63.
  7. Lavretsky H. et al. The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia // International journal of geriatric psychiatry. 2008. Vol. 10. P. 1040-1050.
  8. Massimo L. et al. Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration // Dementia and geriatric cognitive disorders. 2009. Vol. 1. P. 96-104.
  9. Reijnders J.S., Leentjens A.F. Diagnosis and assessment of psychopathological symptoms in Parkinson’s disease // Tijdschrift voor psychiatrie. 2010. Vol. 9. P. 679-684.
  10. Stanton B.R. et al. Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders // Journal of neurology. 2013. Vol. 10. P. 2481-2490.
  11. Starkstein S.E. et al. Neuroimaging correlates of apathy and depression in Alzheimer’s disease // The Journal of neuropsychiatry and clinical neurosciences. 2009. Vol. 3. P. 259-265.
  12. Tunnard C. et al. Apathy and cortical atrophy in Alzheimer’s disease // International journal of geriatric psychiatry. 2011. Vol. 7. P. 741-748.
  13. Williams G.B., Nestor P.J., Hodges J.R. Neural correlates of semantic and behavioural deficits in frontotemporal dementia // Neuroimage. 2005. Vol. 4. P. 1042-1051.
  14. Woolley S.C. et al. Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI // Amyotrophic Lateral Sclerosis. 2011. Vol. 1. P. 52-58.
  15. Yuen G. S. et al. Neuroanatomical correlates of apathy in late-life depression and antidepressant treatment response // Journal of affective disorders. 2014. Vol. 166. P. 179-186.
  16. Zamboni G. et al. Apathy and disinhibition in frontotemporal dementia Insights into their neural correlates // Neurology. 2008. Vol. 10. P. 736-742.

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Copyright (c) 2016 Avedisova A.S., Zakharova K.V., Gaskin V.V., Samotaeva I.S., Arkusha I.A.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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