БОЛЬ ПРИ ОСТЕОАРТРОЗЕ: СИМПТОМ ИЛИ БОЛЕЗНЬ?



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Рассмотрены основные аспекты боли при остеоартрозе с обсуждением роли ноцицептивной боли как основного компонента болевого синдрома. Приведены свидетельства активации воспаления при остеоартрозе и его значения в патогенезе боли, роль провоспалительных цитокинов, простаноидов и простагландина Е в развитии воспаления и болевого синдрома. Дана оценка центральной сенситизации и нейропатической боли как компонентов болевого синдрома при остеоартрозе. Описана роль полиморфизма генов, кодирующих ряд энзимов, а также канальных белков в развитии и выраженности болевого синдрома. Освещены потенциальные возможности направленной анальгетической терапии у пациентов с остеоартрозом с точки зрения патогенеза боли.

Об авторах

Михаил Сергеевич Протопопов

Казанский государственный медицинский университет

Email: mikhailprotopopov@gmail.com
кафедра госпитальной терапии с курсом эндокринологии 420012, г. Казань, ул. Бутлерова, д. 49

Рашид Асхатович Гиниатуллин

Университет Восточной Финляндии

Куопио, Финляндия, Yliopistonranta 1, PL 1627, 70211

Светлана Анатольевна Лапшина

Казанский государственный медицинский университет

кафедра госпитальной терапии с курсом эндокринологии 420012, г. Казань, ул. Бутлерова, д. 49

Диана Ильдаровна Абдулганиева

Казанский государственный медицинский университет

кафедра госпитальной терапии с курсом эндокринологии 420012, г. Казань, ул. Бутлерова, д. 49

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