The article reviews the main aspects of pain in osteoarthritis (OA). Nociceptive pain is discussed as the main component of pain syndrome. The current evidence for the inflammation activation in OA is described; its role in the pathogenesis of the pain syndrome is discussed. The role of pro-inflammatory cytokines as well as prostanoids and prostaglandin E in developing inflammation and pain in OA is reviewed. The central sensitization and neuropathic pain are estimated as the components of the pain syndrome in OA. The role of a number of channel proteins and enzymes-coding genes polymorphisms in pain development and intensity in patients with OA is described. Perspectives for targeted pain-relieving treatments in patients with OA are discussed considering the pain pathogenesis.


pain .

About the authors

Mikhail S Protopopov

Kazan State Medical University

420012, Каzan, Butlerov str., 49

Rashid A Giniatullin

University of Eastern Finland

Кuopio, Finland, Yliopistonranta 1, PL 1627, 70211

Svetlana A Lapshina

Kazan State Medical University

420012, Каzan, Butlerov str., 49

Diana I Abdulganieva

Kazan State Medical University

420012, Каzan, Butlerov str., 49


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