PAIN AT OSTEOARTHRITIS: SYMPTOM OR DISEASE

Abstract


The article reviews the main aspects of pain in osteoarthritis (OA). Nociceptive pain is discussed as the main component of pain syndrome. The current evidence for the inflammation activation in OA is described; its role in the pathogenesis of the pain syndrome is discussed. The role of pro-inflammatory cytokines as well as prostanoids and prostaglandin E in developing inflammation and pain in OA is reviewed. The central sensitization and neuropathic pain are estimated as the components of the pain syndrome in OA. The role of a number of channel proteins and enzymes-coding genes polymorphisms in pain development and intensity in patients with OA is described. Perspectives for targeted pain-relieving treatments in patients with OA are discussed considering the pain pathogenesis.

Keywords

pain .

About the authors

Mikhail S Protopopov

Kazan State Medical University

Email: mikhailprotopopov@gmail.com
420012, Каzan, Butlerov str., 49

Rashid A Giniatullin

University of Eastern Finland

Кuopio, Finland, Yliopistonranta 1, PL 1627, 70211

Svetlana A Lapshina

Kazan State Medical University

420012, Каzan, Butlerov str., 49

Diana I Abdulganieva

Kazan State Medical University

420012, Каzan, Butlerov str., 49

References

  1. Ревматология. Клинические рекомендации [Под ред. Е.Л. Насонова]. 2-е изд., испр. и доп. М.: ГЭОТАР-Медиа, 2010. 752 с.
  2. Abhishek A., Doherty M. Mechanisms of the placebo response in pain in osteoarthritis // Osteoarthritis Cartilage. 2013. № 21. P. 1229-1235.
  3. Allen K.D., Coffman C.J., Golightly Y.M. et al. Daily pain variations among patients with hand, hip, and knee osteoarthritis. Osteoarthritis Cartilage, 2009. №17. P. 1275-1282.
  4. ArcOGEN-Consortium. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study // Lancet. 2012. № 380 P. 815-823.
  5. Ashraf S., Mapp P.I., Walsh D.A. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis // Arthritis Rheum. 2011. № 63. P. 2700-2710.
  6. Ashraf S., Wibberley H., Mapp P.I. et al. Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis // Ann. Rheum Dis. 2011. № 70. P. 523-529.
  7. Ayis S., Dieppe P. The natural history of disability and its determinants in adults with lower limb musculoskeletal pain // J. Rheumatol. 2009. № 36. P. 583-591.
  8. Bajaj P, Graven-Nielsen T, Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study // Pain. 2001. № 93. P. 107-114.
  9. Bedson J., Croft P.R. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature // BMC Musculoskelet Disord. 2008. № 9. P. 116.
  10. Bellamy N., Buchanan W.W., Goldsmith C.H. et al. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee // J. Rheumatol. 1988. № 15. P. 1833-1840.
  11. Blagojevic M., Jinks C., Jeffery A., Jordan K.P. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis // Osteoarthritis Cartilage. 2010. № 18. P. 24-33.
  12. Brenn D., Richter F., Schaible H. Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain // Arth. Rheum 2007. Vol. 56, № 1. P. 351-359.
  13. Chappell A.S., Ossanna M.J., Liu-Seifert H. et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo controlled trial // Pain. 2009. №146. P. 253-260.
  14. Chu K.L., Chandran P., Joshi S.K. et al. TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain // Brain research. 2011. № 1369. P. 158-166.
  15. Cohen S.B., Proudman S., Kivitz A.J. et al. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee // Arth. Res. Ther. 2011. № 13. P. R125.
  16. Craig A.D, Heppelmann B., Schaible H.G. The projection of the medial and posterior articular nerves of the cat’s knee to the spinal cord // J. Comp Neurol. 1988. № 276. P. 279-288.
  17. Cubukcu D., Sarsan A., Alkan H. Relationships between pain, function and radiographic findings in osteoarthritis of the knee: a cross-sectional study // Arthritis. 2012. Article ID 984060 (E-pub 2012 Nov 19).
  18. Day-Williams A.G., Southam L., Panoutsopoulou K. et al. A variant in MCF2L is associated with osteoarthritis // Am. J. Hum. Genet. 2011. № 89. P. 446-450.
  19. Dominick K.L., Ahern F.M., Gold C.H., Heller D.A. Health-related quality of life and health service use among older adults with osteoarthritis // Arth. Rheum. 2004. № 51. P. 326-331.
  20. Dray A., Read S.J. Arthritis and pain. Future targets to control osteoarthritis pain // Arth. Res. Ther. № 9(3). P. 212.
  21. Duarte R.V., ·Raphael J.H., Dimitroulas T. et al. Osteoarthritis pain has a significant neuropathic component: an exploratory in vivo patient model // Rheumatol Int. 2014. № 34. P. 315-320.
  22. Felson D.T., Lawrence R.C., Dieppe P.A. et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors // Ann. Intern Med. 2000. № 133. P. 635-646.
  23. Felson D.T., Naimark A., Anderson J. et al. The pre- valence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study // Arth. Rheum. 1987. № 30. P. 914-918.
  24. Fichter M., Korner U., Schomburg J. et al. Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes // J. Orthop Res. 2006. № 24. P. 63-70.
  25. Fuller S.J., Stokes L., Skarratt K.K. et al. Genetics of the P2X7 receptor and human disease // Purinergic Signal. 2009. № 5. P. 257-262.
  26. Goldring M.B., Marcu K.B. Cartilage homeostasis in health and rheumatic diseases // Arth. Res. Ther. 2009. № 11. P. 224.
  27. Hanesch U., Heppelmann B., Schmidt R.F. Substance P- and calcitonin generelated peptide immunoreactivity in primary afferent neurons of the cat’s knee joint // Neuroscience. 1991. № 45(1). P. 185-193.
  28. Hardy M.M., Seibert K., Manning P.T. et al. Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants // Arth. Rheum. 2002. № 46 (7). P. 1789-1803.
  29. Hattori A., Tanaka E., Murase K. et al. Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in nonneuronal cells // J. Biol. Chem. 1993. № 268(4). P. 2577-2582.
  30. Hawker G.A., Stewart L., French M.R. et al. Understanding the pain experience in hip and knee osteoarthritis-an OARSI/OMERACT initiative. // Osteoarthritis Cartilage. 2008. №16. P. 415-422.
  31. Hill C.L., Hunter D.J., Niu J. et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis // Ann. Rheum. Dis. 2007. № 66 P. 1599-1603.
  32. Hochman J.R., French M.R., Bermingham S.L., Hawker G.A. The nerve of osteoarthritis pain // Arth. Care Res. (Hoboken). 2010. № 62. P. 1019-1023.
  33. Homandberg G.A., Wen C., Hui F. Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid // Osteoarthritis Cartilage. 1998. № 6. P. 231-244.
  34. Hughes J.P., Hatcher J.P., Chessell I.P. The role of P2X 7 in pain and inflammation // Purinergic Signal. 2007. № 3. P. 163-169.
  35. Lembeck F., Donnerer J., Colpaert F.C. Increase in substance P in primary afferent nerves during chronic pain // Neuropeptides. 1981. № 1. P. 175-180.
  36. Levine J.D., Clark R., Devor M. et al. Intraneuronal substance P contributes to the severity of experimental arthritis // Science. 1984. № 226(4674). P. 547-549.
  37. Loeser R., Goldring S., Scanzello C., Goldring M. Osteoarthritis. A Disease of the Joint as an Organ // Arthr. Rheum. Vol. 64. № 6. P. 1697-1707.
  38. Lundblad H., Kreicbergs A., Jansson K.A. Prediction of persistent pain after total knee replacement for osteoarthritis // J. Bone Joint Surg Br. 2008. № 90. P. 166-171.
  39. Magnano M.D., Chakravarty E.F., Broudy C. et al. A pilot study of tumor necrosis factor inhibition in erosive/inflammatory osteoarthritis of the hands // J. Rheumatol. 2007. № 34. P. 1323-1327.
  40. Malfait A.M., Arner E.C., Song R.H. et al. Proprotein convertase activation of aggrecanases in cartilage in situ // Arch. Biochem Biophys. 2008. № 478 P. 43-51.
  41. Malfait A-M., Seymour A.B., Gao F. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype // Ann. Rheum. Dis. 2012 № 71(6). P. 1042-1048.
  42. McAlindon T.E., Cooper C., Kirwan J.R., Dieppe P.A. Determinants of disability in osteoarthritis of the knee // Ann. Rheum. Dis. 1993. № 52. P. 258-262.
  43. Merskey H., Bogduk N. Classification of Chronic Pain, 2nd ed, IASP Press, Seattle, 1994. 238 p.
  44. Neogi T. The epidemiology and impact of pain in osteoarthritis // Osteoarthritis Cartilage. Sep 2013. № 21(9). P. 1145-1153.
  45. Neogi T., Frey-Law L., Scholz J. et al. Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state? // Ann. Rheum. Dis. 2013. № 0. P.1-7.
  46. Ohtori S., Orita S., Yamashita M. et al. Existence of a neuropathic pain component in patients with osteoarthritis of the knee // Yonsei Med. J. № 53. P.801-805.
  47. Pearle A.D., Scanzello C.R., George S. et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis // Osteoarthritis Cartilage. 2007. № 15. P. 516-523.
  48. Pessler F., Dai L., Diaz-Torne C. et al. The synovitis of “non-inflammatory” orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis // Ann. Rheum. Dis. 2008. № 67. P. 1184-1187.
  49. Pulai J.I., Chen H., Im H.J. et al. NF-κB mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments // J. Immunol. 2005. № 174. P. 5781-5788.
  50. Relieving Pain in America: A Blueprint for Transforming Prevention, Cure, Education and Research. Washington, DC: The National Academies Press. 2011. 382 p.
  51. Rosenberg J.M., Harrell C., Ristic H. The effect of gabapentin on neuropathic pain // Clin. J. Pain. № 13. P. 251-255.
  52. Safieh-Garabedian B., Poole S., Allchorne A. et al. Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia // Br. J. Pharmacol. 1995. № 115(7). P. 1265-1275.
  53. Salo P. The role of joint innervation in the pathogenesis of arthritis // CJS. 1999. Vol. 42, № 2. P. 91-100.
  54. Salo P.T., Theriault E.T. Number, distribution, and neuropeptide content of rat knee joint afferents // J. Anat. 1997. № 190. P. 515-522.
  55. Scanzello C.R., McKeon B., Swaim B.H. et al. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms // Arth. Rheum. 2011. № 63. P. 391-400.
  56. Schaible H.G. Mechanisms of chronic pain in osteoarthritis // Curr. Rheum. Rep. № 14. P. 549-556.
  57. Schaible H-G., Grubb B.D. Afferent and spinal mechanisms of joint pain // Pain. 1993. № 55. P. 5-54.
  58. Schaible H.G., Schmidt R.F. Activation of group III and group IV sensory units in medial articular nerve by local mechanical stimulation of the knee joint // J. Neurophysiol. 1983. № 49. P. 35-44.
  59. Schultz R.A., Miller D.C., Kerr C.S., Micheli L. Mechanoreceptors in human cruciate ligaments. A histological study // J. Bone Joint Surg [Am]. 1984. № 66. P. 1072-1076.
  60. Thakur M., Dawes J.M., McMahon S.B. Genomics of pain in osteoarthritis // Osteoarthritis Cartilage. 2013. № 21. P. 1374-1382.
  61. Thakur M., Dickenson A.H., Baron R. Osteoarthritis pain: nociceptive or neuropathic? // Nat. Rev. Rheumatol. 2014. № 10(6). P. 374-380.
  62. Theriault E., Marshall K.W., Homonko D.A. Maintained peptidergic innervation of the knee joint in an animal model of antigen-induced arthritis // Regul Pept. 1993. № 46. P. 204-207.
  63. Torres L., Dunlop D.D., Peterfy C. et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis // Osteoarthritis Cartilage. 2006. №14. P. 1033-1040.
  64. Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis // Biochim Biophys Acta. 2012. №1824. P. 133-145.
  65. Valdes A.M., De Wilde G, Doherty S.A. et al. The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis // Ann. Rheum. Dis. 2011. № 70. P. 1556-1561.
  66. van Meurs J.B.J., Uitterlinden A.G., Stolk L. et al. A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain // Arth. Rheum. 2009. № 60. P. 628-629.
  67. Walsh D.A., Bonnet C.S., Turner E.L. et al. Angioge-nesis in the synovium and at the osteochondral junction in osteoarthritis // Osteoarthritis Cartilage. 2007. № 15. P. 743-751.
  68. Walsh D.A., McWilliams D.F., Turley M.J. et al. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis // Rheumatology (Oxford). 2010. № 49. P. 1852-1861.
  69. Wetzel C.H., Connelly J.F. Use of gabapentin in pain management // Ann. Pharmacother. № 31. 1082-1083.
  70. Woolf C.J. Central sensitization: Implications for the diagnosis and treatment of pain // Pain. 2011. № 152. P. S2-S15.
  71. Yaksh T.L. Substance P release from knee joint afferent terminals modulation by opioids // Brain Res. 1988. № 458. P. 319-324.
  72. Yaksh T.L., Dirig D.M., Conway C.M. et al. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1 // J. Neurosci. № 21(16). P. 5847-5853.
  73. Yamauchi J., Chan J.R., Miyamoto Y. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration // Proc. Natl. Acad. Sci. USA. 2005. № 102. P. 5198-5203.

Statistics

Views

Abstract - 73

PDF (Russian) - 20

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2015 Protopopov M.S., Giniatullin R.A., Lapshina S.A., Abdulganieva D.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies