REVIEW OF METHODS FOR PHARMACEUTICAL ANALYSIS OF SULFUR-CONTAINING ANTIOXIDANTS


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Abstract

Antioxidant protection is an effective and recognized way to control the free-radical oxidative mechanism in live organisms. Antioxidants are widely used in the treatment of hepatitis, atherosclerosis, and malignancies. One of the promising directions for the synthesis of new antioxidants is the inclusion of sulfur in its structures. Sulfur is an element that is easily oxidized and, in addition, is able to bind heavy metal cations. Methods for pharmaceutical analysis of such pharmaceuticals should estimate adeguate the condition of important functional groups and, if it is possible, correlate with antioxidant effect. In this research work methods for guality control of sulfur-containing antioxidant in pharmaceuticals and biosamples are reviewed. For this reason methods for analysis of thioctic acid, probucol, bucillamine and disulfiram, represented in European Pharmacopoeia 8th edition, USP 41, British Pharmacopoeia 2016, Japanese Pharmacopoeia 17th edition, were analysed. It was estimated, that along with reliable pharmacopoeial guantification methods, such as titrimetry, spectrophotometry, and high-performance liguid chromatography, electrochemical methods are being actively developed for the analysis of antioxidants. These methods can be used definitely or as detection for chromatography. Quantitative de- termination based on the redox potential of antioxidants can adequately reflect the functional state of such pharmaceuticals and thus guarantee its efficacy. Due to their high sensitivity and relative ease of sample preparation, electrochemical methods can also be used to determine the content of sulfur-containing antioxidants in biological samples. However, most of the considered methods of analyzing drugs in biosamples are chromatographic. This is because HPLC allow to determine at once pharmaceuticals and its metabolites, and HPLC-MS enable to identify the structure of metabolites.

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About the authors

T. G Shinko

Novosibirsk State Medical University

Email: shinko.tatiana@yandex.ru
Post-graduate Student, Pharmaceutical Department Novosibirsk, Russia

S. V Terentyeva

Novosibirsk State Medical University

Email: terentyeva_sv@mail.ru
Dr.Sc. (Pharm.) Novosibirsk, Russia

E. A Ivanovskaya

Novosibirsk State Medical University

Email: el-ivanovskaja@yandex.ru
Dr.Sc. (Pharm.), Professor Novosibirsk, Russia

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