Features of metabolism and spectrum of action of selenium, possibilities of application of selene-containing food supplements under SARS-CoV-2 pandemic conditions


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Abstract

This article provides a literary review of domestic and foreign sources reflecting the prevalence of selenium (Se) in the environment, its metabolism in the human body. It has been shown that Se deficiency is associated with cardiovascular diseases, disorders in the endocrine and reproductive system. The role of Se in the antioxidant defense system that supports the redox homeostasis of the cell and the body, for example, in viral infections, one of the causes of which is oxidative stress, is presented. The above sources also reflect the positive role of Se in viral infections, including, with a new coronavirus infection caused by the SARS-CoV-2 virus, since Se is necessary for the differentiation and proliferation of a number of immune cells involved in the processes of innate and adaptive immunity. It has been proven that in moderate doses, the Se supplement increases the proliferation of T cells and the activity of natural killer cells. In this regard, it is possible to recommend taking dietary supplements containing Se in high-risk areas and /or shortly after suspected infection with SARS-CoV-2. Positive research results, as well as a good safety profile, indicate the possibility of using biologically active food additives containing Se in complex therapy, in particular SELENBIO for women in disorders of the cardiovascular, endocrine, reproductive system, as well as in infectious diseases.

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About the authors

E. V. Okladnikova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation

Email: potupchik_tatyana@mail.ru

Ph.D. (Med.), Associate Professor of the Department of Pharmacology and Clinical Pharmacology with a Postgraduate Course

T. V. Potupchik

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation

Email: potupchik_tatyana@mail.ru

Ph.D. (Med.), Associate Professor of the Department of Pharmacology and Qinical Pharmacology with a Postgraduate Course

L. S. Evert

Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences"; Research Institute of Medical Problems of the North - a Separate Division; Khakass State University named after N.F. Katanov

Email: potupchik_tatyana@mail.ru

Dr.Sc. (Med.), Chief Researcher, the Clinical Department of Somatic and Mental Health of Children; Professor, the Department of General Professional Disciplines, Medical, Psychological and Social Institute

O. F. Veselova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation

Email: potupchik_tatyana@mail.ru

Ph.D. (Med.), Head of the Department of Pharmacology and Qinical Pharmacology with a Postgraduate Course

Ya. E. Shirobokov

Samara State Medical University

Author for correspondence.
Email: potupchik_tatyana@mail.ru

Post-graduate Student, Department of Management and Economics of Pharmacy

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