Antibacterial properties of organotellurium compounds. Problems of biological, medical and pharmaceu-tical chemistry
- Authors: Israpilova A.I.1, Adieva A.A.1, Jafarova A.M.2, Abakarov G.M.2, Amirkhanova I.V.1
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Affiliations:
- Institute of Biological Resources of the Dagestan Federal Research Center of the RAS
- Dagestan Federal Research Center of the RAS
- Issue: Vol 27, No 2 (2024)
- Pages: 35-42
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/627113
- DOI: https://doi.org/10.29296/25877313-2024-02-04
- ID: 627113
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Abstract
Introduction. Antimicrobial resistance in bacteria has become a global challenge for public health systems. Bacteria that pose the greatest threat to human health due to their increasing resistance to antibiotics include Escherichia coli, Staphylococcus aureus and Salmonella spp.
The purpose of the work is to study the antibacterial properties of three tellurium derivatives against infections caused by Staphylococcus, Escherichia coli and Salmonella.
Material and methods. The object of study is heterocyclic tellurium derivatives. A comparative analysis of the antibacterial properties of the synthesized tellurium derivatives on bacterial strains of Staphylococcus, Escherichia coli and Salmonella was carried out. To determine the antibacterial properties, the serial dilution method was used. The sensitivity of bacteria to the test tellurium derivatives and to antibiotics was assessed using the disk- diffusion method.
Results. The study of three tellurium derivatives in different concentrations made it possible to determine the minimum inhibitory concentration (MIC) for organotellurium compounds, which were 1.35, 0.12 and 0.2 μg of the substance per 1 disk, respectively. For dioxysirocyclo-[4-methylphenyl] tellurochloride against E. coli and S. aureus, the minimum inhibitory concentrations (MIC50) were determined to be 16.4 and 18.6 μg of the substance per 1 disk, respectively.
Conclusions. The effect of organotellurium substances in relatively low concentrations on strains of bacteria Staphylococcus, Escherichia coli and Salmonella indicates the prospects for further study of the biological properties of tellurium derivatives containing various groups.
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About the authors
A. I. Israpilova
Institute of Biological Resources of the Dagestan Federal Research Center of the RAS
Author for correspondence.
Email: ms.israpilova98@bk.ru
ORCID iD: 0009-0001-6318-595X
Post-graduate Student, Institute of Biological Resources
Russian Federation, Makhachkala, Republic of DagestanA. A. Adieva
Institute of Biological Resources of the Dagestan Federal Research Center of the RAS
Email: adieva-m@mail.ru
Dr.Sc. (Biol.), Professor of the Department of Natural Sciences, Caspian Institute of Biological Resources
Russian Federation, Makhachkala, Republic of DagestanA. M. Jafarova
Dagestan Federal Research Center of the RAS
Email: albina19764@mail.ru
ORCID iD: 0000-0001-7744-859X
Ph.D. (Biol.), Associate Professor of the Department of Biochemistry and Biophysics
Russian Federation, Makhachkala, Republic of DagestanG. M. Abakarov
Dagestan Federal Research Center of the RAS
Email: kh@dstu.ru
ORCID iD: 0000-0002-9225-9321
Dr.Sc. (Chem.), Professor, Head of the Department of Chemistry
Russian Federation, Makhachkala, Republic of DagestanI. V. Amirkhanova
Institute of Biological Resources of the Dagestan Federal Research Center of the RAS
Email: ms.israpilova98@bk.ru
ORCID iD: 0000-0002-3436-6276
Ph.D. (Biol.), Research Scientist, Caspian Institute of Biological Resources
Russian Federation, Makhachkala, Republic of DagestanReferences
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