Indicators of local oral immunity in users of new types of tobacco products
- Authors: Ostrovskaya I.G.1, Abramova M.Y.1, Parshkov V.V.1, Mamatsashvili V.G.1
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Affiliations:
- Russian University of Medicine
- Issue: Vol 27, No 7 (2024)
- Pages: 40-45
- Section: Medical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/634415
- DOI: https://doi.org/10.29296/25877313-2024-07-06
- ID: 634415
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Abstract
Introduction. The organs and structures of the oral cavity are among the first to come into contact with the aerosol when using elec- tronic cigarettes and heated-tobacco products, and some of the aerosol components enter various biological fluids of the mouth, inevi- tably provoking a response of the body to external influences. One of the markers of the response are immunoglobulins, and their analysis is intended to help in studying the effect of electronic cigarettes and heated-tobacco products on humans.
Objective. The aim of the study was to estimate changes in immunoglobulins A, G and M of gingival fluid, oral fluid and saliva among users of new types of tobacco products.
Material and methods. The study included 4 groups of 5 people each: regular cigarette smokers, e-cigarette users, users of tobacco heating systems and non-smokers. For laboratory studies, gingival fluid, saliva and oral fluid were taken from the subjects.
Results. Various changes in the concentration of immunoglobulins relative to the control group were observed in all groups of smok- ing patients.
Conclusion. The results may indicate inhibition of the function of local immunity both when exposed to tobacco smoke and when ex- posed to aerosol of heated-tobacco products or electronic cigarettes, which increases the vulnerability of organs and structures of the oral cavity to pathogenic microorganisms.
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About the authors
I. G. Ostrovskaya
Russian University of Medicine
Author for correspondence.
Email: pit.vadim@mail.ru
ORCID iD: 0000-0001-6788-4945
Dr.Sc. (Med.), Professor
Russian Federation, st. Dolgorukovskaya 4, building 1, 127006, MoscowM. Ya. Abramova
Russian University of Medicine
Email: pit.vadim@mail.ru
ORCID iD: 0000-0001-7762-1540
Dr.Sc. (Med.), Professor
Russian Federation, st. Dolgorukovskaya 4, building 1, 127006, MoscowV. V. Parshkov
Russian University of Medicine
Email: pit.vadim@mail.ru
ORCID iD: 0009-0005-0074-3140
Post-graduate Student
Russian Federation, st. Dolgorukovskaya 4, building 1, 127006, MoscowV. G. Mamatsashvili
Russian University of Medicine
Email: pit.vadim@mail.ru
ORCID iD: 0009-0001-5571-9958
Post-graduate Student
Russian Federation, st. Dolgorukovskaya 4, building 1, 127006, MoscowReferences
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