The ambiguous role of the matricellular protein tenascin-C in skin wound healing

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Traditional methods for treating extensive skin injuries have certain limitations regarding; therefore, the search for innovative materials and approaches to optimize wound regeneration processes continues to require particular attention. One of the less-studied extracellular matrix proteins in the context of skin wound healing is Tenascin-C (TN-C). At present, its role as a biomarker in tumor processes has been studied in considerable detail, while data on its regenerative properties remain limited. This article examines the mechanisms of action of TN-C, its interactions with cellular structures and signaling pathways, and summarizes the findings of existing studies that highlight its therapeutic potential in stimulating tissue regeneration and improving healing outcomes. TN-C exhibits a multidomain structure, with each domain interacting with specific ligands. This paper presents a deeper understanding of the functional characteristics of each domain, yielding updated information on the properties of TN-C. The review also aims to identify gaps in current knowledge and to determine directions for future research in the field of regenerative medicine. The aim of the study is a comprehensive analysis of current data on the protein Tenascin-C and its potential role as an active component in the process of skin wound healing. The informational and analytical search was conducted through the examination and synthesis of contemporary scientific data available on electronic resources such as PubMed, Web of Science, ScienceDirect, Scopus, Google Scholar, and eLibrary. The literature search was performed using the following keywords: Tenascin-C, wound healing, matricellular proteins, and cell proliferation. Articles published over the past 20 years were analyzed. Based on the results of the literature review, it can be concluded that additional preclinical studies of the investigated protein TN-C as a wound regeneration stimulator are warranted, specifically during the inflammatory and proliferative phases. In the remodeling phase, it may be more appropriate to utilize inhibitors of TN-C expression to avoid the formation of hypertrophic scars.

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作者简介

A. Asyakina

Kuban State Medical University of Public Health Care of Russia

编辑信件的主要联系方式.
Email: alevtina.asyakina@mail.ru
ORCID iD: 0000-0002-5596-7783
SPIN 代码: 4328-3599

Post-graduate Student of the Department of Fundamental and Clinical Biochemistry, Junior Research Laboratory Assistant of the Central Research Laboratory

俄罗斯联邦, Mitrofana Sedina str., 4, Krasnodar, 350063

K. Melkonyan

Kuban State Medical University of Public Health Care of Russia

Email: kimelkonian@gmail.com
ORCID iD: 0000-0003-2451-6813
SPIN 代码: 2461-8365

Ph.D. (Med.), Associate Professor, Head of the Central Research Laboratory

俄罗斯联邦, Mitrofana Sedina str., 4, Krasnodar, 350063

T. Rusinova

Kuban State Medical University of Public Health Care of Russia

Email: rusinova.tv@mail.ru
ORCID iD: 0000-0003-2962-3212
SPIN 代码: 9591-0848

Researcher Laboratory of the Central Research Laboratory

俄罗斯联邦, Mitrofana Sedina str., 4, Krasnodar, 350063

D. Soloviy

Kuban State Medical University of Public Health Care of Russia

Email: dima.solovey.1987@mail.ru
ORCID iD: 0009-0009-5359-7086
SPIN 代码: 1186-1513

Post-graduate Student of the Department of Fundamental and Clinical Biochemistry

俄罗斯联邦, Mitrofana Sedina str., 4, Krasnodar, 350063

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2. Fig. 1. Domain structure of the TN-C polypeptide chain

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3. Fig. 2. Synthesis of substances involved in the wound regeneration process

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