Disturbance of the night melatonin secretion in patients with the metabolic phenotype of osteoarthritis

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Abstract

Introduction. The high prevalence of obesity increases the importance of understanding the control of disease progression and associated metabolic abnormalities. Recent studies have revealed melatonin as a cause of degenerative joint diseases and a molecular link between sleep disorders and metabolic diseases, due to its powerful biological functions that have a specific effect on the metabolism of osteochondral tissue. Thus, melatonin plays an important role in the regulation of the sleep/wake cycle, adaptation to environmental changes and is considered a key mediator of pathological processes such as osteoarthritis.

Aim – to assess the severity of somnological disorders and the level of nocturnal secretion of the pineal hormone melatonin in patients with the metabolic phenotype of osteoarthritis.

Material and Methods. 80 patients has took part in the study. Participants were divided into 2 groups: group 1 – patients without joint pathology and normal body mass index; group 2 - patients with the metabolic phenotype of osteoarthritis. The subjects underwent a collection of complaints, anamnesis, as well as a general clinical and orthopedic examination. Serum melatonin levels were determined.

Results. Patients with the metabolic phenotype of osteoarthritis showed dysfunction in scores on the subcomponents of sleep quality and quantity. Patients demonstrated a tendency to daytime sleepiness, dissatisfaction with sleep duration, and frequent awakenings at night, which may be due to pain and symptoms of osteoarthritis. It was found that patients with the metabolic phenotype of osteoarthritis showed a decrease in nocturnal excretion of the pineal gland hormone melatonin in comparison with patients in group 1.

Conclusions. The findings support the growing evidence of a significant interaction between melatonin secretion and metabolically associated diseases.

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About the authors

D. R. Shodiev

Ryazan State Medical University

Author for correspondence.
Email: shodiev.dima@yandex.ru
ORCID iD: 0000-0002-4530-2964
SPIN-code: 3556-4398

Post-graduate Student of Department of Biochemistry

Russian Federation, Vysokovoltnaya str., 9, Ryazan, 390026

V. I. Zvyagina

Ryazan State Medical University

Email: vizvyagina@yandex.ru
ORCID iD: 0000-0003-2800-5789
SPIN-code: 7553-8641

Dr.Sc. (Med.), Associated Professor of Department of Biochemistry

 

Russian Federation, Vysokovoltnaya str., 9, Ryazan, 390026

M. N. Ryabova

Ryazan State Medical University

Email: rmn62doc@yandex.ru
ORCID iD: 0000-0002-1707-2567
SPIN-code: 2077-3173

Ph.D. (Med.), Associated Professor of Department of General Surgery, Traumatology and Orthopedics

Russian Federation, Vysokovoltnaya str., 9, Ryazan, 390026

Yu. A. Marsyanova

Ryazan State Medical University

Email: yuliyamarsyanova@yahoo.com
ORCID iD: 0000-0003-4948-4504
SPIN-code: 4075-3169

Assistent of Department of Biochemistry

Russian Federation, Vysokovoltnaya str., 9, Ryazan, 390026

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2. Fig. 1. The level of night melatonin seсretion in the blood serum of the studied groups of patients pg/ml

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3. Fig. 2. Correlation between the level of nighttime melatonin secretion in the blood serum and the level of symptom severity according to the KOOS scale in patients of group 2

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