Adaptive Behavior and the State of Functional Activity of the Endogeneous Opioid System
- Authors: Zuykov A.V.1, Semenova T.P.1, Kozlovskiy I.I.1, Zakharova N.M.1, Andreeva L.A.1, Kozlovskaya M.M.1, Zuikov AV2, Semenova ТP2, Kozlovskiy II3, Zakharova NM2, Andreeva LA4, Коzlovskaya MM5
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Affiliations:
- Institute of Cell Biophysics Russian Academy of Sciences
- Pedagogical Institute of Physical Culture of Moscow Pedagogical University
- Institute of Molecular Genetics, RAS
- Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 9, No 1-2 (2009)
- Pages: 2510-2516
- Section: Articles
- URL: https://journals.eco-vector.com/1606-8181/article/view/322011
- DOI: https://doi.org/10.17816/phbn322011
- ID: 322011
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Abstract
BACKGROUND: It has been established that the endogenous opiates and peptides play important role in the regulation of cognitive processes and stress resistance in numerous species. In this study we present the effects of the opiate antagonist naloxone and selank, the tuftsin analogue with anxiolitic and nootropic activity, on adaptive behavior of the hibernator, ground squirrel. The role of the functional activity of the brain opioid system (OS) in the regulation of adaptive behavior of hibernators has been studied.
METHODS: The functional activity of OS was changed by injecting naloxone (1 mg/kg), an opioid receptor blocker, and the selank (300 μg/kg), which is capable of inhibiting brain enkephalinase. The experiments were performed on Jakutian long-tailed ground squirrels Spermophilus undulatus (n = 19) in the spring and autumn periods of the annual cycle. The adaptive behavior was studied in a stress situation by the method of «open field» and in new surroundings using the «holeboard» method.
RESULTS: It was shown that selank activated the parameters of adaptive behavior in both experimental situations. Naloxone reduced the adaptive capacity caused by the selank-induced activation of OS, impairing the adaptive behavior in the open field. The effect of naloxone was most clearly pronounced in the autumn period of the annual cycle.
CONCLUSIONS: The results demonstrate the interrelationship of the effects of naloxone and the selank on the functional activity of OS and the adaptive behavior of ground squirrels in the transition periods of the annual cycle: the entry to, and arousal from hibernation. [in Russian with English Summary].
Citation: Psychopharmacol Biol Narcol. 2009; 9(1-2): 2510-2516
Keywords
About the authors
Aleksey Vladimirovich Zuykov
Email: avzuykov@rambler.ru
Tat'yana Pavlovna Semenova
Email: tat_semenova@mail.ru
Igor' Igorevich Kozlovskiy
Email: ikozlovskiy@mail.ru
Nadezhda Mikhaylovna Zakharova
Email: n.m.zakharova@gmail.com
Lyudmila Aleksandrovna Andreeva
Email: landr@img.ras.ru
Marina Mikhaylovna Kozlovskaya
Email: ignata@fromru.com
A V Zuikov
Institute of Cell Biophysics Russian Academy of Sciences
Email: avzuykov@rambler.ru
; Institute of Cell Biophysics Russian Academy of Sciences
Т P Semenova
Institute of Cell Biophysics Russian Academy of Sciences
Email: tat_semenova@mail.ru
; Institute of Cell Biophysics Russian Academy of Sciences
I I Kozlovskiy
Pedagogical Institute of Physical Culture of Moscow Pedagogical University
Email: ikozlovskiy@mail.ru
; Pedagogical Institute of Physical Culture of Moscow Pedagogical University
N M Zakharova
Institute of Cell Biophysics Russian Academy of Sciences
Email: n.m.zakharova@gmail.com
; Institute of Cell Biophysics Russian Academy of Sciences
L A Andreeva
Institute of Molecular Genetics, RAS
Email: landr@img.ras.ru
; Institute of Molecular Genetics, RAS
M M Коzlovskaya
Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: ignata@fromru.com
; Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
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