Experimental treatment of induced fetal retardation in model animals
- 作者: Bespalova O.N.1, Blazhenko A.A.1
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隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 14, 编号 1 (2023)
- 页面: 15-22
- 栏目: Review
- URL: https://journals.eco-vector.com/1606-8181/article/view/321619
- DOI: https://doi.org/10.17816/phbn321619
- ID: 321619
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详细
Intrauterine retardation is one of the major complications of pregnancy. This pathology occurs in approximately 10% of all pregnancies in developed countries and >20% in developing countries. Moreover, intrauterine retardation is more frequently associated with stillbirths than other pathologies. Despite studies conducted in the past 50 years, no generally accepted therapeutic regimen has yet been developed. Numerous drugs have been used for treatment; however, none of them has been proven effective. Moreover, after years of testing, new data are emerging about the side effects of the drugs previously used.
Various models of fetal retardation have been developed throughout the study of this problem. The main model animals are rats, pigs, and sheep. Numerous techniques and drug options have been proposed for the treatment of simulated intrauterine developmental delays in these animals. The main amino acids used for treatment were arginine, glutamine, taurine, and citrulline. Thus, the literature review aimed to analyze which model animals and experimental models of intrauterine retardation treatment most adequately reflect the effectiveness of these drugs.
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作者简介
Olesya Bespalova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: shiggerra@mail.ru
ORCID iD: 0000-0002-6542-5953
SPIN 代码: 4732-8089
Scopus 作者 ID: 57189999252
Researcher ID: D-3880-2018
MD, Dr. Sci. (Med.)
俄罗斯联邦, 3 Mendeleevskaya Line, Saint Petersburg, 199034Aleksandra Blazhenko
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: alexandrablazhenko@gmail.com
ORCID iD: 0000-0002-8079-0991
SPIN 代码: 8762-3604
junior research assistant
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